The drug release system is a process in which a bioactive substance discharged from a drug product and enters the process of absorption, distribution and metabolism to deliver its pharmacological action. The drug release is maintained at a specific rate to maximize the benefits as well as to suppress the side impacts. The release rate behaviour is affected by physiological conditions such as ion charge, pH level and enzymatic environment. Since the intestinal tract itself varies broadly in a pH environment, hence it is important to study the profile of drug release in different pH conditions. Mathematical model turns out very useful in predicting the drug release as well as reducing experimental works. The objective of this work was to study the mathematical model in describing the drug release profile in gastrointestinal tract liquid simulation. The release profiles of furosemide and sodium-iron chlorophyllin encapsulation were studied in the pH ranges 1.3-1.5 and 6.8-7.4 to simulate the different part of gastrointestinal tract acidity. The Korsemeyer-Peppas, Weibull and Gompertz were applied in describing the profile. Korsmeyer-Peppas model shows more superior (R2>0.912) than Weibull and Gompertz in describing the release kinetic of furosemide and sodium-iron chlorophyllin encapsulations in both pHs of GTS. The n values of Korsmeyer-Peppas are mostly less than 0.5 suggesting the release mechanism was governed by diffusion.

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The international standards for top glucomannan flour require a minimum of 70% glucomannan. The glucomannan content of Amorphophallus oncophyllus flour was approximately 60%, with starch as the major impurity. Elimination of starch was expected to increase the purity of glucomannan. The purpose of this research was to study starch hydrolysis of the flour using α-amylase. Temperature (35.5-84.5 o C), time (0.4-3.6 h) and pH (2.2-8.8) of hydrolysis were selected as independent variables. A central composite design of response surface methodology (RSM) was performed to obtain the optimum condition. This approach was a novelty of this enzymatic purification of A. oncophyllus. Glucomannan content, starch content, and solubility were chosen as the response variables. The models were reliable for predicting the responses (R 2 ≥ 0.771). It was predicted that the highest glucomannan content (93.0%) obtained at the lowest starch content (1.14%), which hydrolysed at pH 6.17, 84.5 o C and 3.6 h. Prior the verification of the optimum hydrolysed condition from the model, the glucomannan and starch content was 81.59% and 2.27%, respectively. After purification, the absorbance of the β-1,4 glycosidic bond increased as a sign of higher glucomannan purity. A less rough surface and irregular shape of the grain morphology was observed after purification.

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