At the cellular scale, single-neurons process information mainl y through spikes or action potentials [1]. Although the t y pes of s y naptic plasticity and the range of times cales over which the y operate suggest that synapses have a more active role in information processing, the parameter space still remains unexplored. We used a mathematical model of cerebellar granule cell to explore information transmission in mossy fibre -granule cell s y napse of the cerebellum. The impact of plasticit y changes in excitator y synaptic release probabilit y and variation in intrinsic excitability of granule cell was studied combining the modulator y effects of inhibition. We explore the changes in pre and post s y naptic factors and report their influence on first spike latenc y and spike amplitude, revealing the indicators of information encoding in individual neurons [2].
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.