Characterizing information transmission in cerebellar granule neuron

Abstract

At the cellular scale, single-neurons process information mainl y through spikes or action potentials [1]. Although the t y pes of s y naptic plasticity and the range of times cales over which the y operate suggest that synapses have a more active role in information processing, the parameter space still remains unexplored. We used a mathematical model of cerebellar granule cell to explore information transmission in mossy fibre -granule cell s y napse of the cerebellum. The impact of plasticit y changes in excitator y synaptic release probabilit y and variation in intrinsic excitability of granule cell was studied combining the modulator y effects of inhibition. We explore the changes in pre and post s y naptic factors and report their influence on first spike latenc y and spike amplitude, revealing the indicators of information encoding in individual neurons [2].