Aim: Many studies have showed that myalgia is a common onset symptom in coronavirus disease 2019 (COVID-19). This study aimed to determine the frequency of muscle pain in patients followed with COVID-19 diagnosis, and to investigate the relationship between muscle pain and creatine kinase (CK), pH, lactate and lactate dehydrogenase (LDH) levels. Material and Methods: One hundred ten patients diagnosed with COVID-19 in our hospital were included retrospectively in this study. Presence of myalgia at the time of admission and on the 14th day of control were investigated. The first admission laboratory findings, 3rd day CK values and 14th day control CK values of all patients were recorded retrospectively from their files. Results: The study included 110 patients diagnosed with COVID-19. Fifty patients (45.5%) had muscle pain at the time of admission, and it was one of the most common musculoskeletal complaints. High CK results were obtained in 48 (43.6%) of the 110 patients at the time of admission. Thirty-two (66.7%) of 48 patients with high CK had muscle pain (p<0.001). In the patients with muscle pain, the CK levels observed on 1 st , 3 rd , and 14 th day of the disease were found to be significantly higher than in those without muscle pain (p<0.001, p=0.003, p=0.029). No significant relationship was found between complaints of muscle pain and lactate, pH, and LDH values. Conclusion: Since some patients may only present with musculoskeletal symptoms such as myalgia, it is important that clinicians consider COVID-19 in patients presenting with myalgia and high CK levels.
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