COVID-19 Hastalarında Myalji Sıklığı ve Kreatin Kinaz Düzeyleri ile İlişkisi

Abstract

Aim: Many studies have showed that myalgia is a common onset symptom in coronavirus disease 2019 (COVID-19). This study aimed to determine the frequency of muscle pain in patients followed with COVID-19 diagnosis, and to investigate the relationship between muscle pain and creatine kinase (CK), pH, lactate and lactate dehydrogenase (LDH) levels. Material and Methods: One hundred ten patients diagnosed with COVID-19 in our hospital were included retrospectively in this study. Presence of myalgia at the time of admission and on the 14th day of control were investigated. The first admission laboratory findings, 3rd day CK values and 14th day control CK values of all patients were recorded retrospectively from their files. Results: The study included 110 patients diagnosed with COVID-19. Fifty patients (45.5%) had muscle pain at the time of admission, and it was one of the most common musculoskeletal complaints. High CK results were obtained in 48 (43.6%) of the 110 patients at the time of admission. Thirty-two (66.7%) of 48 patients with high CK had muscle pain (p<0.001). In the patients with muscle pain, the CK levels observed on 1 st , 3 rd , and 14 th day of the disease were found to be significantly higher than in those without muscle pain (p<0.001, p=0.003, p=0.029). No significant relationship was found between complaints of muscle pain and lactate, pH, and LDH values. Conclusion: Since some patients may only present with musculoskeletal symptoms such as myalgia, it is important that clinicians consider COVID-19 in patients presenting with myalgia and high CK levels.

The Musculoskeletal Involvement After Mild to Moderate COVID-19 Infection

“…The case reports and original articles comprised only individuals who were treated in intensive care units (ICU) or received sub-intensive or intermediate care, normally with ventilator support during the diseases’ course. Usually, these studies report the visible muscle wasting of the hospitalized patients ( Andrade-Junior et al, 2021 ; Giraudo et al, 2021 ; Kumar et al, 2021 ), as well as musculoskeletal complications such as rhabdomyolysis ( Alrubaye and Choudhary, 2020 ; Zhang Q. et al, 2020 ; Chan et al, 2020 ; Khosla et al, 2020 ; Solís et al, 2020 ; Byler et al, 2021 ; Haroun et al, 2021 ), myalgia ( Mukherjee et al, 2020 ; Uçaroğlu Can et al, 2020 ; Batur et al, 2021 ; De Rosa et al, 2021 ; Vasiliadis et al, 2021 ), cachexia ( Anker et al, 2021 ), critical illness myopathy ( Cabañes-Martínez et al, 2020 ; Islam et al, 2021 ), generalized weakness ( Chan et al, 2020 ; Rosato et al, 2020 ; Paneroni et al, 2021 ), and increased levels of serum CK ( Chan et al, 2020 ; Khosla et al, 2020 ; Batur et al, 2021 ; Byler et al, 2021 ; De Rosa et al, 2021 ; Haroun et al, 2021 ; Orsucci et al, 2021 ; Pitscheider et al, 2021 ).…”

Health Complications in Patients Recovering from COVID-19: A Narrative Review of Post-COVID Syndrome

“…Central sensitization and hyper-responsivity to pain have been identified as the primary pathophysiological etiologies of myalgia and CFS [35,36]. Some studies have discussed whether SARS-CoV-2 can affect skeletal muscle cells by binding with ACE2 alone or with other pro-inflammatory cytokines, resulting in cell damage and expression of growth factors, with excessive stimulation of the dorsal root ganglia [37].…”

“…Short-and long-term musculoskeletal complications are anticipated in patients recovering from moderate to severe COVID-19 symptoms. As such, researchers have proposed that COVID-19 outpatients would likely benefit from physiotherapy and rehabilitation programs similar to those offered to patients recovering from SARS [39], as myalgia and fatigue from Long Covid do not appear to respond as well to classic analgesics [37].…”

Nursing Management Of The Patient Developing Quadriplegia Due To Neurological Involvement After Covid-19: A Case Report

“…6 Moreover, COVID-19 is thought to trigger many neuromuscular diseases through the genetic or immune system or cause the progression of the existing neuromuscular disease. 7 In neurological symptoms occurring in COVID-19 infection, a multidisciplinary approach should be adopted.…”