ÖzetAmaç: Serviks kanseri, gelişmekte olan ülkelerde kadınlarda kansere bağlı ölümlerin önde gelen nedenidir. Bu makalede, bölümümüze başvuran kadın hastaların klinik parametrelerini değerlendirerek, smear sonuçları ile karşılaştırmak istedik. Gereç ve Yöntem:Kadın doğum polikliniğimize 2010-2011 yılı arası başvuran 1101 kadının Bethesda sistemine göre değerlendirilen smear sonuçları, retrospektif klinik verilerle değerlendirildi. Bulgular:Yaş arttıkça enflamasyon tanısının normal izlenmesine oranla anlamlı olarak azaldığı (p=0.001), akıntı-ağrı şikayetinin anlamlı olarak arttığı (p<0.0001), kanama ve kitle hissi şikayetinin değişmediği saptandı (sırasıyla, p=0.978 ve 0.688). Mann-Whitney U testi ile rahim içi araç (RİA) varlığı durumunda aktinomiçes enfeksiyonunun, RİA yokluğu durumuna oranla anlamlı olarak arttığı gözlendi (p<0.0001). Pap smear sonuçlarına bakıldığında, önemi bilinmeyen atipik skuamöz hücreler/düşük dereceli skuamöz intraepitelyal lezyon (ASC-US/LSIL) oranı %11.1 olduğu tespit edildi.Sonuç: Servikovajinal tarama yönteminin, en güvenli ve en kolay tarama yöntemi olduğunu ve gereği halinde doku biyopsisi ile erken tanı şansının daha da yükseleceğini umuyoruz.

Basal cell carcinoma (BCC) is a malignant neoplasm derived from nonkeratinizing cells that originate from the basal layer of the epidermis and it is the most common type of skin cancer in humans. Giant BCC (i.e. greater than 5 cm in diameter) is quite rare and comprises 0.5 percent of all BCC. Despite the high incidence of BCC, metastasis of this tumor is rare, with rates ranging from 0.0028% to 0.55% of all BCC cases. In this case, the tumour reached a giant size and had a pulmonary metastasis.,We aimed to emphasize that although BCC's are usually indolent; the importance of adequate surgery and chemoradiotherapy should always be considered in indicated cases. Keywords: Basal cell carcinoma, metastasis, giant size, adequate surgery ÖzetBazal hücreli karsinom (BHK) epidermisin bazal tabakasından kaynaklanan ve nonkeratinize hücrelerden oluşan en yaygın cilt tümörüdür. Dev BHK (yani çapı 5 cm'den büyük) oldukça nadirdir ve tüm BHK'ların %0,5' ini oluşturmaktadır. BHK insidansı yüksek olmasına rağmen, bu tümörün metastaz oranı tüm vakaların %0,0028-%0,55 arasında değişmektedir. Bu vakada tümör dev boyuta ulaştı ve akciğer metastazı vardı. Burada, BHK'lar genellikle yavaş seyirli olmasına rağmen gerekli vakalarda yeterli cerrahi ve kemoradyoterapinin önemini vurgulamak istedik.Anahtar sözcükler: Bazal hücreli karsinom, metastaz, dev çap, yeterli cerrahi Geliş tarihi

Papillary thyroid carcinoma is the most common type of thyroid cancer; metastases occur more frequently in lymph nodes and less often in the lung and bone. Cutaneous metastases from papillary thyroid carcinoma are extremely rare; this is the first case report of the cutaneous metastasis of papillary thyroid carcinoma that developed on the site of incision for thyroidectomy. Most cutaneous metastases in a surgical scar occur as a result of the implantation of tumor cells or direct extension during surgery and usually appear within a year of surgery. 2,7 The present patient is unusual because the interval between thyroidectomy and the development of cutaneous metastasis to the operation scar was five years.Several mechanisms for the occurrence of cutaneous metastasis from internal malignancy have been proposed, including direct extension, hematogenous spread, lymphatic spread, and the implantation of exfoliated tumor cells during surgery. 5 Tumor cell implantation during surgery may be the most likely pathogenesis of metastasis to a surgical scar. However, in the present case, this is less likely because systemic metastases had been detected three years prior to the development of the skin lesion, and the period between the thyroidectomy and the cutaneous metastasis extended to five years. Alternatively, an alteration in local lymphatic drainage in the region of the scar may be the mechanism responsible for tumor cell implantation. Although hematogenous metastasis is possible, why the metastasis occurred in the scar rather than elsewhere remains open to question.Assuming that this was not a random phenomenon, we suggest that there is a predilection for metastasis to occur at an operation scar as a result of an alteration in the microscopic anatomy around the scar, including in the lymphatic channels, or because the local environment of the scar is more susceptible to metastatic tumor cells. It is possible that this may reflect an altered adhesion molecule profile or altered local immunosurveillance mechanisms. In conclusion, although the exact pathogenesis of metastasis remains unknown, we report this case of a papillary thyroid carcinoma metastasis on a thyroidectomy scar on the neck as representing an interesting occurrence.

Schwannoma is a benign, asymptomatic, solitary, and encapsulated tumor that grows slowly from peripheral, autonomic, or cranial nerve sheaths. The origin of the schwannomas in the facial nerve is rare and they tend to occur in the intratemporal part of the nerve. An intraparotid facial nerve schwannoma is usually a painless, slow-growing mass like the other benign parotid tumors. In this case report, we will discuss the clinical presentation, management, and outcome of two patients with intraparotid facial nerve schwannoma. How to cite this article: Topuz MF, Genç O, Kadioglu N, et al. Intraparotid Facial Nerve Schwannoma: A Report of Two Cases. Int J Otorhinolaryngol Clin 2020;12(1):4–7.

Approximately, one fourth of women have leiomyomas. Leiomyomas are benign tumors that originated from smooth muscle cells. Estrogen is claimed to relate as a cause but exact mechanism has not fully understood. In this study, 95 leiomyoma cases that have been diagnosed by our department in years between 2010 and 2012 were examined. Age ranges of patients, sizes, locations, and numbers of leiomyomas were identified. Immunohistochemically ER (estrogen), PR (progesterone), and Gross cystic disease fluid protein-15 stains were performed to the paraffin blocks and their percentages of staining were noted. Statistically, submucosal and intramural locations were significantly related to ER and PR (p \ 0,001). There were significant relationship between ER and PR in 30-50 years age group (p \ 0,001). There were significant relationship between ER, PR and locations (p \ 0,001), numbers (p \ 0,001), sizes of leiomyomas (below 5 cm; p \ 0,001), (between 5 and 10 cm; p = 0,037), larger than 10 cm; p = 0,002). Consequently, relationship between leiomyoma and ER, PR were revealed in this study. Also, relationship between leiomyoma locations and patient ages were identified statistically. There was no immunoreactivity with GCDFP-15 in leiomyomas.