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Personalized medicine requires the integration and processing of vast amounts of data. Here, we propose a solution to this challenge that is based on constructing Digital Twins. These are high-resolution models of individual patients that are computationally treated with thousands of drugs to find the drug that is optimal for the patient.

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Long lived (0.8 ms, 6 ms, and > 3.8 s) states in C0 2+ have been observed for the first time by monitoring beams of 75-300 keV ions in the ion storage ring ASTRID. It is the first experimental evidence that a doubly charged molecule can be stable on a time scale of seconds. The results are theoretically interpreted by means of a multichannel Schrodinger analysis based on ah initio computations of potential energy curves and off-diagonal spin-orbit couplings. This analysis indicates that 3 n(v=0) accounts for the long lived component. The two decay components in the ms range probably derive from higher excited states in C0 2+ .

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Colorectal tumors are continuously exposed to an inflammatory environment, which together with mitogenic signals sustain several cancer hallmarks. Nuclear factor-kappa B (NFκB) is a major regulator of inflammation and variation in NFκB-associated genes could potentially be used as biomarkers to identify patients with increased risk of colorectal cancer (CRC) development, and/or a rapidly progressing disease. In this study, 348 CRC cases and 806 randomly selected healthy individuals from southeastern Sweden were examined with regard to seven polymorphisms in NFκB pathway-associated genes. Log-rank-tests and Cox proportional hazard regression analysis examined the association between the polymorphisms and CRC-specific survival, whereas chi-square tests and logistic regression analysis were used to test for associations between the polymorphisms and CRC susceptibility. Gene expression and loss of heterozygosity analyses of TNFAIP3 were carried out in a subset of tumors to assess its role as a tumor suppressor in CRC. Heterozygous and polymorphic TNFAIP3 (rs6920220), heterozygous NLRP3 (Q705K) and polymorphic NFκB -94 ATTG ins/del genotypes were found to be associated with poorer survival in patients diagnosed with invasive CRC (aHR = 5.2, 95% CI: 2.5-10.9, P < 0.001). TNFAIP3 mRNA levels were significantly decreased in tumors compared with adjacent non-neoplastic mucosa (P < 0.0001) and loss of heterozygosity of 6q23.3 (TNFAIP3) was detected in 17% of cases, whereas only 2.5% of the investigated specimens displayed TNFAIP3 gene mutations. We propose that TNFAIP3 (rs6920220), NLRP3 (Q705K) and NFκB -94 ATTG ins/del polymorphisms are associated with poor survival in patients with advanced CRC and may be used as prognostic markers. Experimental results indicate that TNFAIP3 may act as a tumor suppressor in CRC.

An implementation of exterior complex scaling using the finite elements method with high degree polynomials is presented. We apply the method to find the resonances of the potential 7.5r 2e−r and of a phenomenological coupled channel model of the CaH molecule. In both cases the method is quickly convergent and extremely stable numerically. Convergence could be pushed to the point where the real parts of most resonance energies were independent of the complex scaling angle and of the exterior scaling radius within machine precision (14 significant digits). All imaginary parts were stable to at least eight significant digits. Several resonances of CaH which had evaded searches with a finite difference method could be located.

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