Background and Motivation: The novel coronavirus causing COVID-19 is exceptionally contagious, highly mutative, decimating human health and life, as well as the global economy, by consistent evolution of new pernicious variants and outbreaks. The reverse transcriptase polymerase chain reaction currently used for diagnosis has major limitations. Furthermore, the multiclass lung classification X-ray systems having viral, bacterial, and tubercular classes—including COVID-19—are not reliable. Thus, there is a need for a robust, fast, cost-effective, and easily available diagnostic method. Method: Artificial intelligence (AI) has been shown to revolutionize all walks of life, particularly medical imaging. This study proposes a deep learning AI-based automatic multiclass detection and classification of pneumonia from chest X-ray images that are readily available and highly cost-effective. The study has designed and applied seven highly efficient pre-trained convolutional neural networks—namely, VGG16, VGG19, DenseNet201, Xception, InceptionV3, NasnetMobile, and ResNet152—for classification of up to five classes of pneumonia. Results: The database consisted of 18,603 scans with two, three, and five classes. The best results were using DenseNet201, VGG16, and VGG16, respectively having accuracies of 99.84%, 96.7%, 92.67%; sensitivity of 99.84%, 96.63%, 92.70%; specificity of 99.84, 96.63%, 92.41%; and AUC of 1.0, 0.97, 0.92 (p < 0.0001 for all), respectively. Our system outperformed existing methods by 1.2% for the five-class model. The online system takes <1 s while demonstrating reliability and stability. Conclusions: Deep learning AI is a powerful paradigm for multiclass pneumonia classification.
Background and Motivation: COVID-19 has resulted in a massive loss of life during the last two years. The current imaging-based diagnostic methods for COVID-19 detection in multiclass pneumonia-type chest X-rays are not so successful in clinical practice due to high error rates. Our hypothesis states that if we can have a segmentation-based classification error rate <5%, typically adopted for 510 (K) regulatory purposes, the diagnostic system can be adapted in clinical settings. Method: This study proposes 16 types of segmentation-based classification deep learning-based systems for automatic, rapid, and precise detection of COVID-19. The two deep learning-based segmentation networks, namely UNet and UNet+, along with eight classification models, namely VGG16, VGG19, Xception, InceptionV3, Densenet201, NASNetMobile, Resnet50, and MobileNet, were applied to select the best-suited combination of networks. Using the cross-entropy loss function, the system performance was evaluated by Dice, Jaccard, area-under-the-curve (AUC), and receiver operating characteristics (ROC) and validated using Grad-CAM in explainable AI framework. Results: The best performing segmentation model was UNet, which exhibited the accuracy, loss, Dice, Jaccard, and AUC of 96.35%, 0.15%, 94.88%, 90.38%, and 0.99 (p-value <0.0001), respectively. The best performing segmentation-based classification model was UNet+Xception, which exhibited the accuracy, precision, recall, F1-score, and AUC of 97.45%, 97.46%, 97.45%, 97.43%, and 0.998 (p-value <0.0001), respectively. Our system outperformed existing methods for segmentation-based classification models. The mean improvement of the UNet+Xception system over all the remaining studies was 8.27%. Conclusion: The segmentation-based classification is a viable option as the hypothesis (error rate <5%) holds true and is thus adaptable in clinical practice.
Background and motivation: Lung computed tomography (CT) techniques are high-resolution and are well adopted in the intensive care unit (ICU) for COVID-19 disease control classification. Most artificial intelligence (AI) systems do not undergo generalization and are typically overfitted. Such trained AI systems are not practical for clinical settings and therefore do not give accurate results when executed on unseen data sets. We hypothesize that ensemble deep learning (EDL) is superior to deep transfer learning (TL) in both non-augmented and augmented frameworks. Methodology: The system consists of a cascade of quality control, ResNet–UNet-based hybrid deep learning for lung segmentation, and seven models using TL-based classification followed by five types of EDL’s. To prove our hypothesis, five different kinds of data combinations (DC) were designed using a combination of two multicenter cohorts—Croatia (80 COVID) and Italy (72 COVID and 30 controls)—leading to 12,000 CT slices. As part of generalization, the system was tested on unseen data and statistically tested for reliability/stability. Results: Using the K5 (80:20) cross-validation protocol on the balanced and augmented dataset, the five DC datasets improved TL mean accuracy by 3.32%, 6.56%, 12.96%, 47.1%, and 2.78%, respectively. The five EDL systems showed improvements in accuracy of 2.12%, 5.78%, 6.72%, 32.05%, and 2.40%, thus validating our hypothesis. All statistical tests proved positive for reliability and stability. Conclusion: EDL showed superior performance to TL systems for both (a) unbalanced and unaugmented and (b) balanced and augmented datasets for both (i) seen and (ii) unseen paradigms, validating both our hypotheses.
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