~Boscialin (l), a new compound structurally related to the ionones and abscisic acid, and its 4-0-ylucoside 2 were isolated from the MeOH extract of the leaves of the African medicinal plant Boscra salrcrfolra The structures of the two compounds were determined mainly by NMR spectroscopy and by acid hydrolysis of the glycoside
Streptomyces antibioticus strain TU 99, from which a wide variety of active compounds had been isolated previously, was reinvestigated using an HPLC photoconductivity screening system. Four new compounds were isolated, characterized and their constitutions determined. All four were alpha, beta-unsaturated gamma-lactones; the most abundant compound 3 (C10H16O4), as well as compound 1 (C9H14O4) had a hydroxy group at C(5) of the lactone ring. The four lactones showed antibiotic activity against Pseudomonas aeruginosa and also a weak inhibition of the chitinase from Serratia marcescens.
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