The progress in the modeling of exotic nuclei with an extreme neutron-to-proton ratio is discussed. Two topics are emphasized: (i) the quest for the universal microscopic nuclear energy density functional and (ii) the progress in the continuum shell model.

BACKGROUND AND PURPOSESignalling through phospholipase C (PLC) controls many cellular processes. Much information on the relevance of this important pathway has been derived from pharmacological inhibition of the enzymatic activity of PLC. We found that the most frequently employed PLC inhibitor, U73122, activates endogenous ionic currents in widely used cell lines. Given the extensive use of U73122 in research, we set out to identify these U73122-sensitive ion channels. EXPERIMENTAL APPROACHWe performed detailed biophysical analysis of the U73122-induced currents in frequently used cell lines. KEY RESULTSAt concentrations required to inhibit PLC, U73122 modulated the activity of transient receptor potential melastatin (TRPM) channels through covalent modification. U73122 was shown to be a potent agonist of ubiquitously expressed TRPM4 channels and activated endogenous TRPM4 channels in CHO cells independently of PLC and of the downstream second messengers PI(4,5)P 2 and Ca 2+ . U73122 also potentiated Ca 2+ -dependent TRPM4 currents in human Jurkat T-cells, endogenous TRPM4 in HEK293T cells and recombinant human TRPM4. In contrast to TRPM4, TRPM3 channels were inhibited whereas the closely related TRPM5 channels were insensitive to U73122, showing that U73122 exhibits high specificity within the TRPM channel family. CONCLUSIONS AND IMPLICATIONSGiven the widespread expression of TRPM4 and TRPM3 channels, these actions of U73122 must be considered when interpreting its effects on cell function. U73122 may also be useful for identifying and characterizing TRPM channels in native tissue, thus facilitating the analysis of their physiology. AbbreviationsCi-VSP, Ciona intestinalis voltage-sensing phosphatase; IP 3 , inositol-1,4,5-trisposphate; PI5K, PI(4)P-5-kinase; PI(4,5)P 2 , phosphatidylinositol-(4,5)-bisphosphate

Precision calculations of the fine and hyperfine structure of muonic atoms are performed in a relativistic approach and results for muonic 205 Bi, 147 Sm, and 89 Zr are presented. The hyperfine structure due to magnetic dipole and electric quadrupole splitting is calculated in first order perturbation theory, using extended nuclear charge and current distributions. The leading correction from quantum electrodynamics, namely vacuum polarization in Uehling approximation, is included as a potential directly in the Dirac equation. Also, an effective screening potential due to the surrounding electrons is calculated, and the leading relativistic recoil correction is estimated.

Discovery of Vti1b as a novel modulator of TRPV1 during inflammatory pain. Application of functional proteomics to define novel and pain state-dependent binding partners of native TRPV1 in dorsal root ganglia.

A method for precise calculation of the energy corrections due to second order electric quadrupole interactions, as well as mixed electric quadrupole-vacuum polarization in the framework of the dynamic hyperfine structure in heavy muonic atoms is presented. For this, a multipole expansion of the Uehling potential is performed. The approach is applicable for an arbitrary nuclear electric charge distribution. By performing these calculations for muonic Rhenium and Uranium using a deformed Fermi distribution, it is shown that both corrections contribute on a level presumably visible in upcoming experiments.

Highlights d Glabrous skin mechanosensitivity declines in maturing mice until 12 weeks of age d An improved tape assay uncovers similar changes in hairy skin mechanosensitivity d In vitro, Piezo2-mediated mechanotransduction decreases during maturation d Patch-seq finds differential gene expression across mechanosensory neuron types

The theory of the g factor of an electron bound to a deformed nucleus is considered nonperturbatively and results are presented for a wide range of nuclei with charge numbers from Z=16 up to Z=98. We calculate the nuclear deformation correction to the bound electron g factor within a numerical approach and reveal a sizable difference compared to previous state-of-the-art analytical calculations. We also note particularly low values in the region of filled proton or neutron shells, and thus a reflection of the nuclear shell structure both in the charge and neutron number. PACS numbers: 31.30.js, 21.10.FtThe electron's g factor characterizes its magnetic moment in terms of its angular momentum. For an electron bound to an atomic nucleus, the g factor can be predicted in the framework of bound state quantum electrodynamics (QED) as well as measured in Penning traps, both with a very high degree of accuracy. This enables extraction of information on fundamental interactions, constants and nuclear structure. For example, the combination of theory and precise measurements of the bound electron g factor has recently provided an enhanced value for the electron mass [1], and bound state QED in strong fields was tested with unprecedented precision [2][3][4][5]. It also enables measurement on characteristics of nuclei such as electric charge radii, as shown for Si 13+ ion [6], or the isotopic mass difference as demonstrated for 48 Ca and 40 Ca in [7], or, as proposed theoretically, magnetic moments [8]. Also, it was argued that g-factor experiments with heavy ions could result in a value for the fine-structure constant which is more accurate than the presently established one [9]. With planned experiments involving high Z nuclei [10,11] and current experimental accuracies on the 10 −10 level for low Z, it is important to keep track also of higher order effects. In this context, the influence of nuclear size and deformation is critical. In [12], the nuclear shape correction to the bound electron g factor was introduced and calculated for spinless nuclei using the perturbative effective radius method [13,14]. This effect takes the influence of a deformed nuclear charge distribution into account, and changes the g factor on a 10 −6 level for heavy nuclei, thus being potentially visible in future experiments. Therefore, a comparison of experiment and theory for heavy nuclei demands a critical scrutiny of the validity of the previously used perturbative methods, as pointed out in [15].In this paper, we present non-perturbative calculations of the nuclear deformation correction to the bound electron g factor and show the corresponding values for nuclei across the entire nuclear chart, quantifying the nonperturbative corrections and especially observing the appearance of nuclear shell closure effects in the values of the bound electron g factor.Relativistic units with =c=1 are used throughout this work, as well as the Heavyside unit of charge with α=e 2 /4π, where α is the fine structure constant and the elementary charge e is neg...

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