Rationale: Bacterial and fungal infections in Coronavirus Disease-19 (COVID-19) patients have been inadequately investigated and reported thus far. The safety profile of tocilizumab (TCZ) administration in candidemia patient still debatable. Patient concerns: A 54 year-old woman presenting with weakness on the left side of her body was diagnosed with COVID-19. After 7 days of admission, her condition worsened and developed respiratory distress and was having respiratory distress despite standard treatment. Diagnoses: Acute respiratory distress syndrome (ARDS) in COVID 19 was diagnoses based on real time-PCR swab, deterioration of PaO 2 /FiO 2 and increased of acute phase reactants. Interventions: Anti Interleukin–6 (IL-6) was considered to tackle her inflammatory condition. Prior to TCZ administration, blood culture was performed and the result came with Candida tropicalis in the absence of bacterial growth. Outcomes: No major complications associated with intravenous antifungal or TCZ occurred. After 40 days of hospitalization, the patient's clinical condition improved and was finally discharged. Lessons: This case underscores the safety profile of giving TCZ in candidemia as a secondary infection in severe COVID-19 patient.
Background: Gastroesophageal reflux disease (GERD) is caused by reflux of stomach contents into the esophagus and give the typical symptoms as heartburn. The prevalence of GERD was vary around the world. Prevalence of GERD by endoscopy in Jakarta was 22.8%. Limited data exist to determine the prevalence and related factors of gastroesophageal reflux disease (GERD) in the population without alarm symptoms. Validated GERDq questionnaire can be used easily to diagnose GERD in primary health care. This study aims to know the prevalence of GERD and related factors.Method: This cross-sectional study was conducted in adult dyspepsia patients at General Hospital District of Cilincing from January to March 2016. A validated GERDq questionnaire and a single proportion sample size calculation were used. Results: The prevalence of GERD was 49%, in elderly participants the prevalence was 44%. Of the 104 consecutive participants, 33.7% were male and 66.3% were female. The mean age was 47.6 ± 15.4 years old. The rate of GERD was higher in females than in males (53 vs. 40%, p = 0.189), increased as the age of the participants increased (p = 0.059) and also increased as the body mass index (BMI) of the participants increased (p 0.05). GERD was present in 50% of active or former smokers (p 0.05), 33.3% of daily coffee drinkers (p 0.05), 56.2% of active or former alcohol consumers (p 0.05), and 57.4% of daily tea drinkers (p = 0.049).Conclusion: The prevalence of GERD in dyspeptic patient was still high. There is a relation between GERD and tea consumption.
recommend triple therapy, consist of proton pump inhibitor, Amoxicillin, and Clarithromycin, for the first-line therapy of H. pylori infection. Yet, questions remain regarding the optimal duration of triple therapy. For Asia, APAGE and PGI
ABSTRAKPendahuluan. Berdasarkan World Health Organization (WHO), hipertensi berkaitan dengan 7,5 juta kematian di seluruh dunia atau mencapai 12,8% dari semua kematian. Sedangkan berdasarkan Riset Kesehatan Dasar (Riskesdas) 2013 di Indonesia, hipertensi masih menjadi masalah kesehatan utama dengan prevalensi mencapai 26,5 %. Ketidakpatuhan merupakan penyebab utama kegagalan pengobatan hipertensi dan faktor risiko munculnya komorbiditas kardiovaskuler. Belum ditemukan penelitian sebelumnya yang meneliti kepatuhan kontrol pasien di komunitas suburban. Penelitian ini dilakukan untuk menganalisis besarnya prevalensi pasien yang tidak kontrol setelah pengobatan hipertensi.Metode. Penelitian ini merupakan studi retrospektif, melalui penelusuran rekam medis pada pasien yang berobat antara bulan Oktober -Desember 2015.Hasil. Dari 80 pasien yang menjadi subjek penelitian, rerata usia pasien 57,5 ± 11 tahun, didominasi oleh pasien wanita (68,8%). Berdasarkan klasifikasi European Society of Cardiology (ESC) 2013 prevalensi terbesar adalah hipertensi derajat 2 mencapai 40%. Komorbiditas yang paling banyak dijumpai adalah diabetes melitus sebesar 22,5 %. Enam puluh persen pasien mendapatkan 1 jenis obat dan golongan calcium channel blocker merupakan jenis obat yang tersering diberikan. Prevalensi pasien yang tidak kontrol mencapai 63,8 %. Dari analisais bivariate ditemukan hubungan bermakna antara kepatuhan kontrol dengan jumlah obat yang diberikan (Odds Ratio 10,3; IK 95% 3,1), admisi (Odds Ratio 14,6; IK 95% 4,6), dan komorbid (Odds Ratio 4,3; IK 95% 1,6 -11,4) meskipun dalam analisis multivariat variabel komorbiditas tidak ditemukan kemaknaan.Simpulan. Prevalensi ketidakpatuhan kontrol masih tinggi. Diperlukan penelitian lanjutan untuk mengetahui faktor faktor lain yang menjadi penyebab ketidakpatuhan tersebut.
Introduction:This study aimed to review the clinical characteristics and outcomes of COVID-19 patients presented with in-hospital hyperglycemia or pre-existing type 2 diabetes (T2DM). Methods: This is a retrospective study conducted in Fatmawati General Hospital, Indonesia, from March 18th-Apr 30th, 2020. We reviewed medical records of 27 COVID-19 patients presented with either in-hospital hyperglycemia (11, 12.2%) or pre-existing T2DM (16, 17.8%) from a total of 90 confirmed COVID-19 cases admitted in our hospital. Results: Critical conditions occurred in 50% of T2DM and 54.55% of the in-hospital hyperglycemia group. Mortality was documented in 68.75% of T2DM and 81.82% of in-hospital hyperglycemia group. Hypoglycemia, diabetic ketoacidosis, lactic acidosis and ketosis were found in 12.5%, 25%, 18.75%, and 25% of individuals with T2DM, respectively, resulting in a high mortality rate. Meanwhile, diabetes-related complications were rare among the in-hospital hyperglycemia group. However, respiratory failure (45.45% vs. 6.25%) and septic shock (27.27% vs. 6.25%) were more frequent than in the T2DM group. Conclusion:In this preliminary study, a high mortality rate was documented among COVID-19 patients with preexisting T2DM and in-hospital hyperglycemia. In T2DM subjects, diabetes relatedcomplications contributed to a higher mortality rate, while inhospital hyperglycemia group, respiratory failure and septic shock were more frequent.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.