Masih rendahnya kepatuhan regimen terapi walaupun program prolanis sudah dijalankan menyebabkan kejadian hipertensi di wilayah puskesmas Gombong II dengan kejadian hipertensi yang masih tinggi. Tujuan penelitian: Mengetahui gambaran kepatuhan regimen terapi pada klien hipertensi di wilayah Puskesmas Gombong II. Metode: Penderita hipertensi dengan usia ≥ 18 tahun sampai 65 tahun di Wilayah Puskesmas Gombong II, terdiagnosis hipertensi berdasarkan rekam medis dan bersedia menjadi responden sebagai kriteria inklusi. Desain cross-sectional digunakan pada klien hipertensi sebanyak 107 responden dari tanggal 16 Mei-31 Mei 2019 menggunakan quota sampling. Instrumen Hill-Bone HBP Compliance to High Blood Pressure Therapy Scale digunakan. Didapatkan 9 pernyataan valid dengan nilai korelasi ≥ 0,361 dan 5 pernyataan tidak valid dengan nilai korelasi <0,361. Uji reliabilitas sebesar 0,753(Cronbach Alfa). Hasil: Data dianalisis menggunakan analisis univariat dan bivariat kai square. Didapatkan sebesar 61,7% (n=66) tidak patuh terhadap regimen terapi hipertensi. Sebesar 66,4% patuh terhadap diet rendah garam, 60,7% tidak patuh pemeriksaan rutin ke pelayanan kesehatan, dan 58,9% tidak patuh terhadap konsumsi obat. Ada hubungan antara keanggotaan prolanis dengan kepatuhan regimen terapeutik (pvalue: 0,001). Diskusi: Alasan klien hipertensi tidak patuh regimen terapi karena sudah merasa sehat, mengkonsumsi obat tradisional, ketidaknyamanan karena pengobatan yang kompleks, merasa lupa dan sibuk. Dari ketiga domain kepatuhan, domain pengurangan konsumsi garam dipatuhi oleh sebagian besar responden. Keanggotaan prolanis dapat menjadi faktor yang dapat meningkatkan kepatuhan. Kesimpulan: Penelitian ini menunjukkan sebagian besar responden tidak patuh terhadap regimen terapi, sehingga perlu meningkatkan strategi yang lebih efektif dalam meningkatkan kepatuhan regimen terapi.Kata kunci: Hipertensi, Kepatuhan regimen terapi, Konsumsi Garam, Pemeriksaan rutin, Konsumsi obatABSTRACTThe low adherence to the therapy regimen even though the prolanis program has been implemented has caused the incidence of hypertension in the Gombong II health center area with high incidence of hypertension. The research objective: To determine the description of therapy regimen adherence to hypertensive clients in the area of Gombong II Health Center. Methods: Patients with hypertension aged ≥ 18 years to 65 years in the Gombong II Community Health Center, diagnosed with hypertension based on medical records and willing to become respondents as the inclusion criteria. The cross-sectional design was used for 107 hypertensive clients from 16 May-31 May 2019 using quota sampling. The Hill-Bone HBP Compliance to High Blood Pressure Therapy Scale instrument was used. There were 9 valid statements with a correlation value ≥ 0.361 and 5 invalid statements with a correlation value <0.361. Reliability test of 0.753 (Cronbach Alfa). Results: Data were analyzed using univariate and bivariate kai square analysis. It was found that 61.7% (n = 66) did not adhere to the hypertension therapy regimen. It is said to be obedient if the percentage is ≥80% of filling out the questionnaire and it is said to be disobedient if the percentage is 80%. As much as 66.4% adhered to a low salt diet, 60.7% did not comply with routine checks to health services, and 58.9% did not comply with drug consumption. There is a relationship between prolanis membership and adherence to the therapeutic regimen (p-value: 0.001). Discussion: The reasons for hypertensive clients not adhering to the therapy regimen are because they already feel healthy, take traditional medicine, are uncomfortable due to complex treatment, feel forgetful and busy. Of the three compliance domains, the domain of reducing salt consumption was obeyed by most of the respondents. Prolanis membership can be a factor that can increase compliance. Conclusion: This study shows that most of the respondents do not adhere to the therapy regimen, so it is necessary to develop a more effective strategy in increasing the adherence to the therapy regimen.Key words: Hypertension, adherence to therapy regimens, salt consumption, routine examination, drug consumption