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Background-Endothelium-derived nitric oxide (NO) is synthesised from L-arginine by endothelial nitric oxide synthase (eNOS) encoded by the NOS 3 gene on chromosome 7. Because reduced NO synthesis has been implicated in the development of coronary atherosclerosis, which has a heritable component, we hypothesised that polymorphisms of NOS 3 might be associated with increased susceptibility to this disorder. Methods and Results-Single-strand conformation polymorphism analysis of NOS 3 identified a G3 T polymorphism in exon 7 of the gene which encodes a Glu3 Asp amino acid substitution at residue 298 of eNOS. We investigated the relationship between this Glu

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