Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Serum Beta D glucan has 75%-80% sensitivity and 80% specificity to make a diagnosis of invasive candidiasis. Objectives This study was designed to understand real-world diagnostic utility of S. Beta D Glucan (BDG) on antifungal prescription patterns associated patient outcomes. Methods Study design: Retrospective cohort study Study Population: All consecutive patients who underwent BDG (fungitell assay) testing with conclusive (positive or negative) results in the intensive care unit (ICU) setting between January 1, 2021 to December 31, 2021 at a tertiary care center in western India. Statistical Methods: We assessed the difference in continuous variables across compared groups using the independent samples t-test and binary logistic regression for categorical variables. We summarize the summary results as odds ratio and 95% confidence intervals. All P-values are 2-sided and set at 5% for all comparisons. All data analyses were performed using IBM SPSS ver 28. Results A total of 4481 patients were admitted in the ICU, of which 198 patients underwent BDG testing. Of the 198, 113 tested positive and 61 negative and formed the denominator for the study. Patients with intermediate BDG [24 (12.1%)] were excluded from the analysis. The mean (SD) age for the study cohort was 57.5 (14.7) years with 30.8% female. All the patients were receiving broad-spectrum antibiotics at the time of BDG collection. A total of 24 study patients had a positive blood culture (23 bacterial isolates and 1 Candida parapsilosis). The groups, positive and negative test results for BDG, were comparable for ventilator usage (P = .737), vasopressor prescription (P = .270), history of surgery (P = .791) central line placement (P = .403), liver disease (P = .144), CKD (P = .424), COVID-19 positivity (P = .238), WBC count (P = .137), CRP (P = .769), and serum procalcitonin (P = .784). Patients with ischemic heart diseases (IHD) (P = .013) and acute kidney injury requiring hemodialysis (AKI/HD) (P = .017) were significantly higher in the test positive group. Test negative group patients received early BDG testing, mean (SD) stay of 3.33 (3.77) days as compared to 5.61 for test positive (6.59) days P = .004). More test-positive patients received antifungal therapy (P <.0001), while 20.4% didn't receive antifungals. Caspofungin (25.9%), fluconazole (18.4%), anidulafungin (7.5%), voriconazole (6.9%), and combination antifungal were used in 10.9% of study patients. Logistic regression model showed no difference in mortality between the two groups (P = .413) with higher Odds of mortality in test-positive patients (1.357, 95% CI 0.705- 2.609). Treatment with caspofungin was associated with higher Odds of mortality (3.497; 95% CI 1.324–9.239, P = .012) as compared with fluconazole. Similar trend was observed with anidulafungin (OR: 4.089 95% CI 1.052-15.888, P = .042) as compared to fluconazole. This significance remained for caspofungin [OR 3.607 (1.262 -10.311) P = .017] while anidulafungin [OR: 3.934 (0.965-16.032) P = .56] didn't show significance with the multivariate model. Conclusion Probable invasive candidiasis as diagnosed with positive BDG test doesn't increase the risk of mortality. Patients treated with fluconazole were associated with better survival as compared with caspofungin.
Background: Syphilis is one of the major causes of adverse outcomes in pregnancy in developing countries. Antenatal screening for syphilis aims primarily at timely detecting & treating pregnant women with congenitally transmissible syphilis, there by preventing perinatal deaths. Objective: To study prevalence of syphilis in antenatal women by screening them with the Rapid Plasma Reagin (RPR) & rapid immunochromatographic (ICT) method. Materials and Methods: A total of 2258 pregnant women attending antenatal care from January to December 2018 were tested for Syphilis by RPR & rapid ICT. Results: Out of 2258 women screened during their antenatal visits, 12 (0.53%) were positive by RPR as well as rapid ICT test method. Conclusion(s): Early detection of syphilis in pregnancy is the best tool for prevention of adverse pregnancy outcomes. Antenatal screening of syphilis with Rapid plasma regain (RPR) and Rapid immunochromatography (ICT) is sensitive, specific, rapid and cost-effective method.
INTRODUCTION: Smartphone has become an important device in current day living. It affects our physical activity levels. Excessive usage of smartphone may give impact on day-to-day physical activity. The more time spent on using the smartphones the least time for doing any kind of physical activity. In current time young adults spent their most of the time in using phone which decreases their physical activities. AIM: The current study is aimed to evaluate correlation between smartphone addiction and physical activity among college students across Ahmedabad city. METHOD: An observational study was conducted on college students across Ahmedabad city. International Physical Activity Questionnaire (IPAQ) and Smartphone Addiction Scale – Short Version (SAS-SV) was filled by 106 individuals studying in college and submitted through google form. ethical clearance has been taken. RESULT: Data was analysed using SPSS software version 29. The normality of data was checked by the Kolmogorov-Smirnov test and Data was not normally distributed, spearman’s correlation test was applied to find out the correlation between smartphone addition and physical activity. A strong significant negative correlation found between smart phone addiction and physical activity. (r=-0.805) CONCLUSION: The present study showed that physical activity was significantly lower among smartphone addicts and therefore found a relationship between smartphone addiction and physical activity among students. A person who spends more time on the phone spends less time for physical activity. Key words: College students, physical activity level, IPAQ, smartphone addiction, smartphone addiction scale – short version.
virus was estimated to be higher than that of other seasonal influenza viruses. [4] Influenza A H1N1 infections have been primarily seen among young children, suggesting that they are the most vulnerable to infection. [5] In the clinical diagnosis of influenza, nucleic acid testing by reverse transcriptase polymerase chain reaction (RT-PCR) has widely replaced traditional virus culture owing to shorter turnaround time and increased sensitivity. [6] To limit community or hospital transmission, and to initiate antiviral therapy on time, the rapid detection of the virus in suspected cases remains crucial. [7] Most cases of H1N1 infection present as mild or subclinical pneumonia. With this background, this study was conducted to compare epidemiologic and virologic characteristics of H1N1-positive patients with those of uninfected and those of infected with other seasonal influenza viruses. Background: In April 2009, a new strain of influenza virus, A H1N1, started to spread in various parts of the world, and the first case was reported on May 16, 2009. [1] The associated morbidity and mortality have made it a major health burden. In this study, we have investigated samples of patients with suspected influenza-like illnesses (ILIs) received at civil
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