This article explores the impact of diagnostic/psychiatric labelling on the attitudes and behavioural intentions of school-aged children towards a hypothetical peer presented with symptoms of attention deficit hyperactivity disorder (ADHD). A sample of 120 children aged 11-12 years read one of three vignettes describing the behaviour of a gender-neutral, same-age peer presenting with symptoms of ADHD. The participants completed self-report measures of attitudes and behavioural intentions after reading the respective vignettes. The majority of participants perceived the vignette character as being male and the attitude held towards him was predominately negative. Significant positive relationships were found between attitudes and children's willingness to engage in social, academic and physical activities. Diagnostic/psychiatric labelling had no additional influence upon attitudes or behavioural intentions. Children's negative attitude towards peers with symptoms of ADHD, given its association with friendship choice, is an important target for change in reducing stigma.
Different KLF1 variants may potentially produce variable phenotypes. A framework for investigating KLF1 variants and their phenotypic impact has been provided. In the future, given available international databases, further testing algorithms (as advocated here) will allow for correlation of phenotype with genotype and therefore accurately document this variability between KLF1 variants.
Background: MNS blood group system genes GYPA and GYPB share a high degree of sequence homology and gene structure. Homologous exchanges between GYPA and GYPB form hybrid genes encoding hybrid glycophorins GP(A-B-A) and GP(B-A-B). Over 20 hybrid glycophorins have been characterised. Each has a distinct phenotype defined by the profile of antigens expressed including Mi a. Seven hybrid glycophorins carry Mi a and have been reported in Caucasian and Asian population groups. In Australia, the population is diverse; however, the prevalence of hybrid glycophorins in the population has never been determined. The aims of this study were to determine the frequency of Mi a and to classify Mi a-positive hybrid glycophorins in an Australian blood donor population. Method: Blood samples from 5,098 Australian blood donors were randomly selected and screened for Mi a using anti-Mi a monoclonal antibody (CBC-172) by standard haemagglutination technique. Mi a-positive red blood cells (RBCs) were further characterised using a panel of phenotyping reagents. Genotyping by high-resolution melting analysis and DNA sequencing were used to confirm serology. Result: RBCs from 11/5,098 samples were Mi a-positive, representing a frequency of 0.22%. Serological and molecular typing identified four types of Mi a-positive hybrid glycophorins: GP.Hut (n = 2), GP.Vw (n = 3), GP.Mur (n = 5), and 1 GP.Bun (n = 1). GP.Mur was the most common. Conclusion: This is the first comprehensive study on the frequency of Mi a and types of hybrid glycophorins present in an Australian blood donor population. The demographics of Australia are diverse and ever-changing. Knowing the blood group profile in a population is essential to manage transfusion needs.
Erythroid-specific Krüppel-like factor 1, or KLF1, is an integral transcriptional activator for erythropoiesis. Genetic variants within KLF1 can result in a range of erythropoietic clinical phenotypes from benign to significant. The In(Lu) phenotype refers to changes in the quantitative expression of blood group associated red cell surface molecules due to KLF1 variants which are otherwise clinically benign.These clinically benign KLF1 variants are associated with a reduced expression of one or more red cell membrane proteins/carbohydrates that carry blood group antigens for the LU (Lutheran), IN (Indian), P1PK, LW (Landsteiner-Wiener), KN (Knops), OK, RAPH and I blood group systems. This is of significance during routine serologic blood typing when expression falls below the test sensitivity and therefore impacts on the ability to accurately detect the presence of affected blood group antigens. This is of clinical importance since the transfusion requirements for individuals with the
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