Renal function was monitored in 20, living-related kidney donors before and after uninephrectomy. Urinary protein excretion and retinoid metabolism respectively were studied in 10 and 6 of these donors. The functional adaptation was characterized by an increase in glomerular filtration rate and tubular function, which began in the first two days after uninephrectomy. Changes in tubular function were also demonstrated by significant increases in the urinary excretion of beta 2 microglobulin (beta 2M), retinol binding protein (RBP), kappa and lambda light chains of immunoglobulins. In addition, a protein identical to or homologous to cellular retinoic acid binding protein (CRABP), appeared in the urine after nephrectomy. We did not find CRABP in serum samples either before or after nephrectomy, suggesting that urinary CRABP was synthesized by the remaining kidney. Increases in serum levels of Vitamin A and RBP were also observed in the post-nephrectomy period. These modifications in retinol metabolism suggest that these substances could have a role as renotropic growth factors in compensatory hypertrophy.
Nine cases of superficial pemphigus that were treated by dapsone as the initial mode of therapy are reported. Five patients, all having low or negative serum anti-intercellular cement substance antibody titers, responded dramatically, while the other four patients, showing high titers of anti-intercellular cement substance antibodies, did not respond to this treatment. Complications of therapy were observed in three cases.
Traitement préventif et surveillance 59-9Références 59-9 L es carcinomes cutanés sont les cancers les plus fré-quents de l'adulte ¹ et se divisent globalement en carcinomes basocellulaires (CBC) (trois quarts) et en carcinomes épidermoïdes (CE) (un quart). Les CE sont des tumeurs volontiers agressives et peuvent menacer le pronostic vital par leur capacité à métastaser. Les CE se développent souvent sur des lésions précancéreuses d'où l'importance de la surveillance et des traitements préventifs à ce stade. Les CE touchent la peau et les muqueuses où leur évolution agressive est souvent plus marquée. Les CE sont plus fré-quents chez les sujets immunodéprimés chez qui le rapport CE/CBC est inversé.
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