Acute adaptative changes to unilateral nephrectomy in humans

Argilés, Àngel; Mourad, Georges; Basset, Nicole; Axelrud-Cavadore, Claude; Haiech, Jacques; Mion, C; Cavadore, Jean‐Claude; Demaille, Jacques

doi:10.1038/ki.1987.265

Cited by 39 publications

(32 citation statements)

References 38 publications

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“…In addition, it could be demonstrated that the increase of all three parameters was paralleled by a decrease of the donor's eGFR and correlation analysis revealed a significant inverse association of eGFR with ROH, RBP4 and apoRBP4, respectively. These results confirmed and expanded the observations of Argiles et al [26], who reported an increase of ROH and RBP4 serum concentration in donors seven days after LDKT.…”

Section: Discussionsupporting

confidence: 92%

Vitamin A metabolism is changed in donors after living-kidney transplantation: an observational study

et al. 2011

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BackgroundThe kidneys are essential for the metabolism of vitamin A (retinol) and its transport proteins retinol-binding protein 4 (RBP4) and transthyretin. Little is known about changes in serum concentration after living donor kidney transplantation (LDKT) as a consequence of unilateral nephrectomy; although an association of these parameters with the risk of cardiovascular diseases and insulin resistance has been suggested. Therefore we analyzed the concentration of retinol, RBP4, apoRBP4 and transthyretin in serum of 20 living-kidney donors and respective recipients at baseline as well as 6 weeks and 6 months after LDKT.ResultsAs a consequence of LDKT, the kidney function of recipients was improved while the kidney function of donors was moderately reduced within 6 weeks after LDKT. With regard to vitamin A metabolism, the recipients revealed higher levels of retinol, RBP4, transthyretin and apoRBP4 before LDKT in comparison to donors. After LDKT, the levels of all four parameters decreased in serum of the recipients, while retinol, RBP4 as well as apoRBP4 serum levels of donors increased and remained increased during the follow-up period of 6 months.ConclusionLDKT is generally regarded as beneficial for allograft recipients and not particularly detrimental for the donors. However, it could be demonstrated in this study that a moderate reduction of kidney function by unilateral nephrectomy, resulted in an imbalance of components of vitamin A metabolism with a significant increase of retinol and RBP4 and apoRBP4 concentration in serum of donors.

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Section: Discussionsupporting

confidence: 92%

Vitamin A metabolism is changed in donors after living-kidney transplantation: an observational study

et al. 2011

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“…Although ATRA has been reported to inhibit the compensatory hypertrophy of the kidney after unilateral removal [20], there was no substantial difference in size among the two groups of ATRA-treated mice, the oil-treated controls, and the untreated controls. The splenic weight was also measured to determine whether ATRA could eliminate splenomegaly in IL-6 transgenic mice.…”

Section: Resultsmentioning

confidence: 81%

All-trans-Retinoic Acid Inhibits the Development of Mesangial Proliferative Glomerulonephritis in Interleukin-6 Transgenic Mice

Shima

Iwano²,

Yoshizaki³

et al. 2005

Nephron Exp Nephrol

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All-trans-retinoic acid (ATRA), a vitamin A derivative, was reported to suppress the interleukin-6 (IL-6) production and to downregulate the IL-6 receptor (IL-6R) and/or its signal transducer glycoprotein 130. We investigated the in vivo antinephritic effect of ATRA on IL-6 transgenic mice which had developed mesangial proliferative glomerulonephritis (PGN) as well as its in vitro inhibitory effect on the proliferation of rat mesangial cells. In vivo experiments on IL-6 transgenic mice showed that ATRA administration suppressed proteinuria and hematuria and reduced the IL-6 concentrations; furthermore, histological examination demonstrated that it improved PGN. In vitro experiments using rat mesangial cells demonstrated that ATRA inhibited cell growth in a dose-dependent manner within a range from 10^–4 to 10^–6M. This inhibition by ATRA was partially counteracted by the addition of IL-6. RT-PCR assay results showed that ATRA also reduced IL-6R, but not the glycoprotein 130 expression in mesangial cells. These findings indicate that, by blocking of the IL-6 function, ATRA may be therapeutically effective in PGN.

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“…42,43 A 53% reduction in the glomerular filtration rate has been observed immediately after unilateral nephrectomy. 44 The remaining kidney is, therefore, challenged to face prolonged hyperfiltration. 45 Hemodynamics and structural changes contribute to increased renal blood flow and decreased renal vascular resistance.…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural changes and nestin expression accompanying compensatory renal growth after unilateral nephrectomy in adult rats

Eladl

Elsaed

Atef

et al. 2017

IJNRD

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Background: Several renal disorders affect the glomerular podocytes. Compensatory structural and functional changes have been observed in animals that have undergone unilateral renal ablation. These changes occur as a pliant response to quench the increased functional demand to maintain homeostasis of fluid and solutes. Nestin is an intermediate filament protein present in the glomerular podocytes of the adult kidney and is linked with the maintenance of its foot process structure. Structural changes in the podocytes ultimately restructure the filtration barrier. Very few studies related to the ultrastructural and histopathologic changes of the podocytes are documented. The present study aimed to assess the histopathologic changes at the ultrastructural level in the adapted kidney at different time intervals following unilateral renal ablation in adult rats and its relation with nestin. Methods: Forty-eight rats were divided into four groups (n=12 in each group). The animals of Group A were control naïve rats, while the group B, group C and group D animals underwent left unilateral nephrectomy and the remaining right kidney was removed on days 10, 20 and 30, respectively. Each group included four sham-operated rats, which were sacrificed at the same time as the naïve rats. Each nephrectomized sample was weighed and its sections were subjected to hematoxylin and eosin examination, transmission electron microscopic study as well as immunostaining using the intermediate filament protein nestin. Results: No difference was found between the kidney sections from the control group and the sham-operated groups. A significant increase in the weight of the right kidneys was noted in groups B, C and D (P<0.001). The ultrastructural adaptive changes seen in the glomeruli of group B were subsequently reduced in groups C and D. This finding corresponded to a similar pattern of nestin expression in the podocytes, which showed significant increase in group B followed by reduced expression in groups C and D. Histopathologic and transmission electron microscopic evaluation of group B showed signs of kidney injury. On the other hand, group C animals showed markedly reduced renal adaptive changes and similar changes were also noted in group D. Conclusion: Correlation between nestin expression and the ultrastructural changes confirms that nestin has a role in increasing the mechanical stability of the podocytes in order to enhance their morphologic changes in response to the tensile glomerular capillary wall. However, further studies investigating more remote ultrastructural changes and their relation with nestin expression are needed to confirm this relationship.

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Acute adaptative changes to unilateral nephrectomy in humans

Cited by 39 publications

References 38 publications

Vitamin A metabolism is changed in donors after living-kidney transplantation: an observational study

Vitamin A metabolism is changed in donors after living-kidney transplantation: an observational study

All-trans-Retinoic Acid Inhibits the Development of Mesangial Proliferative Glomerulonephritis in Interleukin-6 Transgenic Mice

Ultrastructural changes and nestin expression accompanying compensatory renal growth after unilateral nephrectomy in adult rats

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