Most historians who have studied the medieval Ardennes have focused exclusively on royal and monastic properties, assuming that every early reference to land in the area is either to the property of royal monasteries or to fiscal land. Actually, the evidence from the region around Bastogne (Belgium), the centre of what would later be called pagus Ardennensis, shows that as early as the seventh century ‘private’ landowners were present and active in the area. This observation leads to a new reading of the rural economy and society, the formation of monastic property and the links between local and royal power in the early medieval Ardennes.

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Background/Aim: Urothelial carcinoma (UC) of the urinary bladder is the second most common tumor in the field of urology and is characterized by a relatively aggressive growth behavior. New therapeutic approaches are required to improve the prognosis of affected patients. We hypothesized a link between dysregulation of eIFs and the development of UC. Therefore, in the present work, we investigated the expression behavior of eIF1, eIF1AY, eIF1AX, eIF2α, eIF3a, eIF3b, eIF4B, eIF4E, eIF4G, eIF5A, eIF5B, and eIF6 in UC compared with that in urothelial tissue. Materials and Methods: Paraffinembedded tumor tissue samples from 107 patients suffering from UC were examined. Seventy-six patients contained adjacent urothelial tissue. Three tumor tissue cylinders (tumor collective) and two urothelial tissue cylinders (control collective) were collected per patient and embedded in tissue microarray (TMA) blocks. Immunohistochemical staining of the TMA sections was then performed. The staining results were assessed semiquantitatively. Staining intensities and immunoreactive scores (IRS) of both collectives were compared. In each case, a distinction was made between cytoplasmic and nuclear staining. Results: Significant up-regulation of eIF1AY, eIF2α, eIF3a, eIF3b, eIF4B, eIF4G, eIF5B, and eIF6 was found in the cytoplasm of UC. In contrast, eIF1 and eIF5A were significantly down-regulated in the cytoplasm of UC. eIF5A and eIF6 were significantly down-regulated in the nuclei of UC. Conclusion: Dysregulation of eIFs in the urothelium of the urinary bladder is linked to carcinogenesis at this site.

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The study of medieval Europe is being transformed as old orthodoxies are challenged, new methods embraced and fresh fields of enquiry opened up. The adoption of interdisciplinary perspectives and the challenge of economic, social and cultural theory are forcing medievalists to ask new questions and to see familiar topics in a fresh light. The aim of this series is to combine the scholarship traditionally associated with medieval studies with an awareness of more recent issues and approaches in a form accessible to the non-specialist reader.