1,2-Disubstituted vinyltrimethylsilanes (1) readily underwent formylation with replacement of the silyl group when treated with dichloromethyl methyl ether and titanium(IV) chloride. This reaction provides a simple procedure for the selective preparation of (E)-2-alkenals (2) and was conveniently applied to the synthesis of ethyl 12-oxo-10(E)-dodecenoate and nuciferal.
Oxidation der Säurehydrazide (I) in Methanol bzw. (VI) in THF mit Cu(O‐Ac), ° H2O (II) im Molverhältnis 2:1 bzw. 8: 1 unter Einleiten von 02 führt zu den Benzoesäuren (III) und den Methylestern (IV) bzw. zu den Säuren (V); letztere lassen sich auch durch Oxidation der Säurehydrazide (VI) mit Cu(OH)2 ‐ erzeugt in situ aus CuCl2 mit KOH in THF ‐ darstellen.
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