Facile oxidative conversion of hydrazides of carboxylic acids to corresponding acids, esters and amides using copper compounds

Aerobic Copper-Catalyzed Organic Reactions

“…1131 Catalytic amounts of Cu(OAc) 2 with continuous bubbling of oxygen through a methanol solution proved to be effective only for the synthesis of carboxylic acids. For the esters and amides, stoichiometric amounts of copper were required.…”

Kinetics of the oxidation of isoniazid with the hypochlorite ion

“…[32][33][34][35][36][37][38] These are as follows: As pseudo-first order conditions could not be applied, the evaluation was based on determining the initial rate 50-51 of absorbance change at 320 nm. [32][33][34][35][36][37][38] These are as follows: As pseudo-first order conditions could not be applied, the evaluation was based on determining the initial rate 50-51 of absorbance change at 320 nm.…”

“…[14][15][16] Hypochlorous acid and its conjugate base, hypochlorite ion, are ubiquitous in biological systems. [32][33][34][35][36][37][38] At this point, it should be mentioned that there is an earlier kinetic study published on the reaction between isoniazid and hypochlorite ion in basic medium. [17][18][19][20][21][22] It is the product of the myeloperoxidase-catalyzed oxidation of chloride ion in the presence hydrogen peroxide 17,22 and may react with a whole range of organic and inorganic reactants in the body.…”

New synthetic applications and biological activity of diazenes

“…We found that thallium(III) nitrate trihydrate (TTN) transformed hydrazides to the corresponding acid derivatives under mild reaction conditions [5]. The reactions probably proceed via the acyl diimide, postulated earlier [6,7], although the formation of the acyl cation has also been suggested [8,9]. The final product can either be an acid, ester or amide, depending on the selection of nucleophile (Scheme 1).…”