Anillin (ANLN), an actin-binding protein, reportedly plays a vital role in cell proliferation and migration, particularly in cytokinesis. Although there have been findings pointing to a contribution of ANLN to the development of cancer, the association of ANLN to cancer remains not fully understood. Here, we gather evidence to determine the applicability of ANLN as a prognostic tool for some types of cancer, and the impact that ANLN has on the hallmarks of cancer. We searched academic repositories including PubMed and Google Scholar to find and review studies related to cancer and ANLN. The conclusion is that ANLN could be a potent target for cancer treatment, but the roles ANLN, other than in cytokinesis and its influence on tumour microenvironment remodeling in cancer development, must be further elucidated, and specific ANLN inhibitors should be found.

Penfluridol has robust antipsychotic efficacy and is a first-generation diphenylbutylpiperidine. Its effects last for several days after a single oral dose and it can be administered once a week to provide better compliance and symptom control. Recently; strong antitumour effects for penfluridol were discovered in various cancer cell lines; such as breast; pancreatic; glioblastoma; and lung cancer cells via several distinct mechanisms. Therefore; penfluridol has drawn much attention as a potentially novel anti-tumour agent. In addition; the anti-cancer effects of penfluridol have been demonstrated in vivo: results showed slight changes in the volume and weight of organs at doses tested in animals. This paper outlines the potential for penfluridol to be developed as a next-generation anticancer drug.

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This paper gives the criteria for the system of initial operators to possess the

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Introduction: Acute cholecystitis due to gallstone disease during pregnancy often requires emergency surgical treatment. Laparoscopic cholecystectomy (LC) can be performed concurrently with cesarean section when surgical management can be delayed until after birth. Case presentation: A 25-year-old female patient was 38 weeks pregnant. On day five, she was taken to the hospital to treat cholecystitis. We performed emergency surgery in collaboration with the obstetrician and gastrointestinal surgery team. A healthy baby weighing 3200 g was born with an Apgar score of 9–10. After the closure of the vertical incision, a pneumoperitoneum was established, and the gallbladder was removed laparoscopically. On the sixth postoperative day, the patient was discharged from the hospital without complications. Discussion: LC was performed immediately following cesarean delivery. The infant delivery diminished the size of the uterus, removing it from the surgical field. LC was thus performed in a safe, effective, and expeditious manner, providing a definitive treatment. Breastfeeding was unaffected because the patients had no dietary restrictions. The recoveries were uncomplicated, with better cosmetic results, short lengths of stay, and reasonable costs. Conclusion: Faster recovery, better cosmetic results, and better lactation outcomes are advantages of LC immediately after cesarean delivery. Highlights