Objectives:
Evaluate the effects of "XGTQ" in the treatment of cirrhosis induced by Carbon tetrachloride (CCL4)
in combination with alcohol and high-fat diet on Wistar rats.
Materials and methods:
Cirrhosis on white rats was induced by subcutaneously injecting CC14 at an initial dose of
5,0ml/kg, followed by 1,2ml/kg once a week in 10 weeks. Then, fed with synthetic food, added 20% fat, and 0.05% cholesterol and iron oxalate. Rats were administered every day with plain water and 1 day with water mixed with 30% ethanol.
The rats were randomly divided into 5 groups and given distilled water (group 1 and 2 or control group), silymarin (group
3 or reference group) or the "XGTQ" drug extract (group 4, 5) for 4 weeks. Collected blood for biochemical test and liver
were dissected to evaluate weight, morphology and quantified 4-hydroxyproline to evaluate fibrosis and collagen accumulation.
Results:
In cirrhotic wistar rats, "XGTQ" drug at 19.6 g/kg/24h and 58.8 g/kg/24h showed the ability of reducing the activity
of enzymes AST, ALT in the blood (p<0.01), increasing plasma albumin and decreasing prothrobin time (p<.05);
improving physical condition, macroscopic and microscopic images of H&E-stained liver; decreasing the concentration of
hydroxyproline in the liver and reducing the level of cirrhosis on the masson-stained templates. The effects of "XGTQ"
increased with the dose, and was equivalent to silymarin at the dose of 70 mg/kg/24h.
Conclusion:
The extract of "XGTQ" drug is effective in treating cirrhosis in Wistar rats.
Traditional medicine has many good remedies, most of them have a preventive and supporting effect in the treatment of cirrhosis, which slows down and reduces the process of cirrhosis. The "XGTQ" remedy, which has been used in the Department of Traditional Medicine -Military Hospital 103 to treat cirrhosis, was formulated from 12 medicinal herbs include Radix Astragali,
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