The Effects of the “XGTQ” Medicine in Treating Cirrhosis in Wistar Rats

Abstract

Objectives: Evaluate the effects of "XGTQ" in the treatment of cirrhosis induced by Carbon tetrachloride (CCL4) in combination with alcohol and high-fat diet on Wistar rats. Materials and methods: Cirrhosis on white rats was induced by subcutaneously injecting CC14 at an initial dose of 5,0ml/kg, followed by 1,2ml/kg once a week in 10 weeks. Then, fed with synthetic food, added 20% fat, and 0.05% cholesterol and iron oxalate. Rats were administered every day with plain water and 1 day with water mixed with 30% ethanol. The rats were randomly divided into 5 groups and given distilled water (group 1 and 2 or control group), silymarin (group 3 or reference group) or the "XGTQ" drug extract (group 4, 5) for 4 weeks. Collected blood for biochemical test and liver were dissected to evaluate weight, morphology and quantified 4-hydroxyproline to evaluate fibrosis and collagen accumulation. Results: In cirrhotic wistar rats, "XGTQ" drug at 19.6 g/kg/24h and 58.8 g/kg/24h showed the ability of reducing the activity of enzymes AST, ALT in the blood (p<0.01), increasing plasma albumin and decreasing prothrobin time (p<.05); improving physical condition, macroscopic and microscopic images of H&E-stained liver; decreasing the concentration of hydroxyproline in the liver and reducing the level of cirrhosis on the masson-stained templates. The effects of "XGTQ" increased with the dose, and was equivalent to silymarin at the dose of 70 mg/kg/24h. Conclusion: The extract of "XGTQ" drug is effective in treating cirrhosis in Wistar rats.

Pelatihan Integrasi Model Pembelajaran dalam Learning Management System (LMS) berbasis Project untuk Meningkatan Kompetensi Pedagogi Guru Sekolah Dasar

“…Melalui media LMS, meaningful learning dapat tercipta dan membuat siswa merasa puas dengan pengalaman pembelajaran (Muhardi, Gunawan, Irawan, & Devis, 2020). Pelatihan LMS untuk guru adalah penting untuk memaksimalkan fungsi dari LMS karena guru adalah sumber utama dalam hal ini (Santiago et al, 2020;Fearnley & Amora, 2020;Thanh Khoa, Ho Chi, Minh Ha, Viet Hoang Nguyen, & Huu Bich, 2020;Oguguo et al, 2020). Hasil kegiatan pengabdian ini konsisten dengan pandangan ini, karena melalui LMS, guru dapat lebih mudah melaksanakan tugasnya dan melakukan evaluasi pembelajaran dengan lebih efektif.…”