The objective of our study was to compare the serum concentrations of procalcitonin (PCT), neopterin, tumor necrosis factor alpha (TNF-α), prostaglandin E2, malondialdehyde, interleukin 8, and gamma interferon (IFN-γ) in neonatal calves with septicemic colibacillosis (n = 15) with healthy controls (n = 15). Septicemic colibacillosis was diagnosed based on clinical signs and the isolation of Escherichia coli from heparinized blood in clinically suspected cases. PCT, neopterin, TNF-α (p < 0.05), and IFN-γ concentrations in calves with septicemic colibacillosis were significantly higher than in the healthy controls (p < 0.01). Serum PCT concentrations were ~4 times higher in the calves with septicemic colibacillosis than in the healthy calves, suggesting that PCT could be a useful marker of septicemic colibacillosis in neonatal calves.

Chronic suppurative otitis media is inflammation of the middle ear and mastoid that involves discharge and hearing loss. Kerstersia gyiorum is a member of the Alcaligenaceae family that who could not be treated with classical treatments such as patients with chronic otitis media, neck abscesses. K. gyiorum strain isolated from a patient with chronic suppurative otitis media.

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In this study, we concluded that the interactions of cytolytic granules containing perforin and caspase cascade and Fas-FasL may play an important role in the pathogenesis of CCHF in children.

Background/Aims. Patients with ulcerative colitis still need effective therapy without major side effects. It has been found that strontium can suppress NFκB activation induced by TNF-α. This opens a gate to a new anti-TNF agent which is cheap and can be given orally. We for the first time aimed to investigate the effect of strontium chloride (SrCl2) on inflammation in experimental colitis. Methods. Thirty female Wistar albino rats were divided into 5 groups each containing 6 rats. The rats in groups 1 and 2 served as the healthy control and colitis group, respectively. The rats in groups 3, 4, and 5 had colitis and received 40 mg/kg SrCl2, 160 mg/kg SrCl2, and 1 mg/kg prednisolone by oral gavage, respectively. The rats were sacrificed for histological evaluation and determination of serum neopterin, TNF-α, and IFN-γ levels. Results. The neopterin, TNF-α and IFNγ levels of group 2 was significantly higher than the other groups. The neopterin, TNF-α, and IFN-γ levels of controls and other treatment groups were comparable. There were a significant difference in macroscopic and microscopic healing between group 2 and other groups histologically. But there was not a significant difference within treatment receiving groups. Conclusion. SrCl2 had comparable therapeutic efficiency with prednisolone.

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Although it is generally accepted that M.bovis leads to tuberculosis in cattle, there are statements given from the different regions of the world, referring to the fact that M. tuberculosis, which is known as the human tuberculosis agent, causes tuberculosis in cattle as well. The material of the study consisted of 13 M. tuberculosis isolates which were isolated and identified from the organ pieces of 95 cattle with the culture methods; these organ pieces had been taken from the cattle with granulomatous lesion detection after the slaughtering in slaughterhouses located in Çukurova region and brought to the laboratory under sterile conditions. It was determined in the genotyping conducted by using the Spoligotyping method that 13 of the 55 isolates were M. tuberculosis and they belonged to the T1 family (SIT53) by becoming dense in one cluster (100%). Consequently, it was shown with this study that M. tuberculosis, which leads to tuberculosis in humans, could be transmitted from humans to animals and from animals to humans again, and researching the human and epidemiological tuberculosis cases by using molecular epidemiology-based methods such as spoligotyping might provide useful information about explaining the ways of transmission of tuberculosis. Türkiye'de Sığırlardan İzole Edilen M. tuberculosis Suşlarının Spoligotiplendirmesi Özet Tüberkülozise sığırlarda, M. bovis'in sebep olduğu genel olarak kabul edilmesine rağmen insan tüberkülozis etkeni olarak bilinen M. tuberculosis'in de sığırlarda tüberkülozise neden olduğuna dair dünyanın farklı bölgelerinden yapılmış bildirimler bulunmaktadır. Çalışmanın materyalini Çukurova bölgesinde bulunan mezbahalarda kesim sonrası granülamatöz lezyon tespit edilen sığırlardan alınan ve steril şartlarda laboratuvara ulaştırılan 95 adet sığıra ait organ parçalarından kültür yöntemleri ile izole ve identifiye edilen 13 adet M. tuberculosis izolatı oluşturdu. Spoligotyping yöntemi ile yapılan genotiplendirmede 55 izolattan 13 tanesinin M. tuberculosis olduğu ve bunların tek bir küme içerisinde yoğunlaşarak (%100) T1 ailesine (SIT53) ait olduğu belirlendi. Sonuç olarak bu çalışma ile insanlarda tüberkülozise neden olan M. tuberculosis'in insanlardan hayvanlara, hayvanlardan da tekrar insanlara bulaşabileceği, insan ve hayvan kaynaklı tüberkülozis vakalarının spoligotyping gibi moleküler epidemiyolojik temelli yöntemlerle araştırılmasının tüberkülozisin bulaş yollarının açıklanması konusunda faydalı bilgiler verebileceği gösterilmiştir.