The Evaluation of Important Biomarkers in Healthy Cattle

Ercan, Nazlı; Tuzcu, Nevin; Başbuğ, Onur; Gök, Kurtuluş; Işidan, Hakan; Oğrak, Yusuf Ziya

doi:10.9775/kvfd.2014.11066

Cited by 12 publications

(16 citation statements)

References 10 publications

(26 reference statements)

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“…PCT, having a long serum half-life (20-30 h), increases rapidly within a short time in bacterial diseases (Brunkhorst et al, 1999;Becker et al, 2004;Shehabi and Seppelt, 2008;Matur et al, 2017). Ercan et al (2014) have stated that PCT concentrations in healthy neonatal calves were decreased compared to healthy young and adult cattle but PCT concentrations were not different in healthy young and adult cattle. Bonelli et al (2018) have found that the average PCT concentrations in calves with septic systemic inflammatory response syndrome (SIRS) were 166.5 pg/ml.…”

Section: Discussionmentioning

confidence: 99%

The use of inflammatory markers as a diagnostic and prognostic approach in neonatal calves with septicaemia

Kirbaş

Kandemir

Çelebi

et al. 2019

Acta Veterinaria Hungarica

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The objective of this study was to evaluate the usefulness of inflammatory markers as a diagnostic and prognostic approach in neonatal calves with septicaemia. The study material consisted of 13 neonatal calves with septicaemia (septicaemic calves, SC) and ten healthy neonatal calves (control calves, CC). Blood samples were collected for biochemical, haematological and microbiological analyses. In addition, faecal samples were collected for microbiological and virological analyses. Three of neonatal calves with septicaemia were positive for E. coli (E. coli O157 serotype) by microbiological examination, but all neonatal calves with septicaemia were negative for rota-and coronaviruses. By haematological examination, there were no significant differences between SC and CC for white blood cell (WBC) and neutrophil (NEU) counts (P > 0.05). NEU counts were higher on day 0 than on day 15 in SC (P < 0.05). Red blood cell (RBC) counts and packed cell volume (PCV) values were higher on day 0 in the SC than in the CC (P < 0.05). By biochemical analyses, tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), procalcitonin (PCT), haptoglobin (Hp), and fibrinogen (Fb) concentrations were higher on day 0 in the SC than in the CC (P < 0.05). After treatment (on day 15), the serum IL-6, PCT, Hp, and Fb concentrations were significantly decreased in the SC compared to the CC (P < 0.05). The serum iron (Fe) concentrations were lower on day 0 in the SC than in the CC (P < 0.05), and were higher on day 15 than on day 0 in the SC (P < 0.05). The study revealed that inflammatory markers could be used for determining the diagnosis and prognosis in neonatal calves with septicaemia.

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Section: Discussionmentioning

confidence: 99%

The use of inflammatory markers as a diagnostic and prognostic approach in neonatal calves with septicaemia

Kirbaş

Kandemir

Çelebi

et al. 2019

Acta Veterinaria Hungarica

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“…Furthermore, these researchers detected that the serum neopterin levels of bacteraemic patients with pneumococcal pneumonia were higher than those of non-bacteraemic pneumonia patients. Ercan et al [33] indicated that in healthy cattle, neopterin levels were significantly higher particularly during the neonatal period, and suggested that this could be related to monocyte activation in new-born animals.…”

Section: Discussionmentioning

confidence: 99%

Lumpy Skin Disease’li Sığırlarda Tümör Nekroz Faktör-alfa, Haptoglobin, Serum Amiloid A ve Neopterin Düzeyleri

Başbuğ¹,

Ağaoğlu²,

Tuzcu³

et al. 2016

Kafkas Univ Vet Fak Derg

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Lumpy skin disease (LSD) is a viral disease of cattle, characterised by the formation of nodules in different parts of the body. In this study, it was conducted to assess the pattern of changes of albumin, tumour necrosis factor-alpha (TNF-α), haptoglobin (Hp), serum amyloid A (SAA) and neopterin levels in cattle with LSD, to assess the clinical course of the disease, and to the demonstration of inflammatory process in cattle with LSD. This study was carried out in 30 cattle, including 20 animals naturally infected with LSD and 10 healthy animals. It was determined that, in the cattle infected with LSD, while albumin concentrations had significantly decreased (P=0.004) in comparison to the control group, Hp (P<0.001), SAA (P<0.001) and neopterin (P<0.001) concentrations had significantly increased. Receiver operating characteristic (ROC) curve was used to calculate the sensitivity and specificity of Hp, SAA and neopterin. The cut-off values of the healthy and infected cattle for Hp, SAA and neopterin were determined to be 0.196 mg/mL, 41.38 µg/mL and 23.93 nmol/mL, respectively. At these cut-off values, high levels of sensitivity (85% for Hp, 95% for SAA and 70% for neopterin) and specificity (90%) were detected. It was determined that SAA levels were of higher sensitivity and specificity compared to Hp and neopterin levels with respect to the demonstration of inflammation associated with LSD. Furthermore, the clinical picture of the disease was found to be significantly correlated with the Hp, SAA and neopterin levels. Keywords: Lumpy Skin

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“…With the passage of microorganisms or toxins through the epithelial layer and into the subepithelial tissue, existing monocytes and macrophages recognize non-indigenous microorganisms entering the body and send the necessary signals to the adhesion molecules in the environment. This signaling event begins to release many cytokines such as TNF-α, IL-6, and IL-8 (Lofstedt et al 1999;Basoglu et al 2004;Ercan et al 2014). Indeed, according to related studies; cytokines reach the highest levels in blood plasma and serum within 60-180 minutes during the development of bacteriemia and endotoxemia (Hack et al 1989;Wakabayashi et al 1991).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of intercellular adhesion molecule-1 (ICAM-1), Tumor necrosis factor α (TNF-α), Interleukins (IL-6, IL-8) and C-reactive protein (CRP) levels in neonatal calves with presumed septicemia

Akgül¹,

Akgül²,

Kozat

et al. 2019

Van Veterinary Journal

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In this study; intercellular molecule-1 (ICAM-1), Tumor necrosis factor α (TNF-α), Interleukin-6 (IL-6), Interleukin-8 (IL-8) and C-reactive protein (CRP) levels were evaluated in neonatal calves with presumed septicemia. The material of this study consisted of a total of 30 calves. Study group consisted of 20 septicemic calves and 10 clinically healthy calves and with same breed and weight and their ages were between 1 and 10 days. The statistical analysis indicated that leukocyte (WBC), red blood cell (RBC), hematocrit (Hct) hemoglobin (Hb) and mean corpuscular haemoglobin concentration (MCHC) values in neonatal calves with presumed septicemia were higher than those of the control group (P<0.05), whereas PLT values of neonatal calves with septicemia were lower than those of the control group (P<0.05). The levels of ICAM-1, TNF-α, IL-6, IL-8 and CRP values in septicemic calves were higher than those of the control group (P<0.05). As a result, it was concluded that analyzes of TNF-α, IL-6, IL-8 and particularly ICAM-1 concentrations may be considered in evaluating the severity and prognosis of patients with septicemia, as well as monitoring the efficacy of the treatment of the disease.

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The Evaluation of Important Biomarkers in Healthy Cattle

Cited by 12 publications

References 10 publications

The use of inflammatory markers as a diagnostic and prognostic approach in neonatal calves with septicaemia

The use of inflammatory markers as a diagnostic and prognostic approach in neonatal calves with septicaemia

Lumpy Skin Disease’li Sığırlarda Tümör Nekroz Faktör-alfa, Haptoglobin, Serum Amiloid A ve Neopterin Düzeyleri

Evaluation of intercellular adhesion molecule-1 (ICAM-1), Tumor necrosis factor α (TNF-α), Interleukins (IL-6, IL-8) and C-reactive protein (CRP) levels in neonatal calves with presumed septicemia

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