The healing capacity of bone marrow mesenchymal stem cells (BMMSCs) has been evaluated in various studies. This study aimed to evaluate the effect of BMMSCs on the healing of temporomandibular joints (TMJs) with induced rheumatoid arthritis. Fifty healthy male Sprague Dawley rats were divided into three groups: group I (n = 10), negative control; group II (n = 20), positive control (induction of arthritis by adjuvant followed by intravenous injection of 0.1 ml of PBS); and group III (n = 20), intervention (as for group II but injected intravenously with 1 × 10 cells ml of BMMSCs suspended in PBS). Half of the rats in each group were euthanized 3 wk after the start of the experiment and the other half was euthanized after 5 wk. Group I revealed normal TMJ features. Group II showed thickening of disc, thinning of cartilage, disordered bone trabeculae, and decreased in mean % area staining positive of collagen fibers at 3 wk, while at 5 wk these effects were more aggravated. Group III showed nearly normal thickness of disc and condylar cartilage, nearly normal arrangement of bone trabeculae and regenerated collagen fibers at 3 wk, while after 5 wk the TMJ features were almost normal. Two-way anova revealed statistically significant differences between groups. Thus, treatment of induced rheumatoid arthritis with BMMSCs shows promising results that need to be further investigated in humans.

No abstract

Hemodialysis (HD) is one of the most important and effective treatment modalities that can help to sustain life of end stage renal disease patient. A large number of HD patients suffer from uremic pruritus(UP). Patient education is an important aspect of clinical management that encourages a continuous and interactive process that looks to improve the patient's lifestyle and thereby prevent or decrease the UP related complications.Aim of this study:Evaluate effect of uremic pruritus educational interventions on knowledge level for hemodialysis patients.Method: Quasi experimentalresearcherdesign was used in this study. Setting:The current study was conducted in hemodialysis unit at General Kafr Elsheikh governorate hospital.Sample:A purposive sample of (80) HD patients with uremic pruritus was randomly divided into two groups with equal size.Tools: Interview questionnaire sheet consisted of three parts such as demographic data, medical data, and assessment of patient knowledge.Results: The current study showed that the average knowledge scores are nearly the same in both study and control groups at pretest, while at posttest there was a statistical significant difference between study and control groups as the average knowledge scores are significantly higher in study group compared to control group. Conclusion: Hypothesis of the current study was accepted as patients who receive the uremic pruritus educational interventions have an increased level of knowledge.