The nose is highly vulnerable to skin cancers due to the unavoidable sun exposure. The most common localization of skin cancers on the face is nose. Although the nose appears to be a single structure, it comprises many aesthetic units with different histological and anatomical properties. Our aim was to determine the relationship between the prevalence of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), histologically and anatomically distinct nasal subunits. The study included patients who underwent excision and repair due to BCC or SCC of the nose. The lesions were classified according to their location in the following topographic subunits: tip, alar lobule, dorsum, sidewall, and medial canthal region. Patients were analyzed according to age, sex, topographic subunit, tumor type, and repair technique. There was no statistically significant difference in tumor location according to etiology (p > 0.05). The alar subunit was the most common location of BCC, while the dorsum was the most common location for SCC. There is no statistical relationship between the two most common skin cancers, BCC and SCC, and the aesthetic subunits of the nose. The only factor associated with the reconstruction method used was the subunit in which the tumor was located.
We aimed to elucidate the role of intraoperative clean surgical margin (iCSM) determined according to lesion size and duration to obtain appropriate histological clean surgical margin (hCSM) in high-risk basal cell carcinoma (BCC) patients evaluated according to National Comprehensive Cancer Network (NCCN) criteria considering the tumor size and/or location. The contribution of lesion area to determine iCSM was also evaluated. Patients with high-risk BCC requiring surgical management were included. iCSM, hCSM, and clinical variables including sec, age, longest edge, location and area, and follow-up duration were recorded. In total, 96 lesions were evaluated. Lesions were mostly located in the mask area and other face region (93.8%). Lesions located on the nose comprised 50%, 34.1%, and 26.3% in the BCC-5, BCC-7, and BCC-10 lesions, respectively. The hCSMs were positive in 11.5%, 9.1%, and 3.8% of the BCC-5, BCC-7, and BCC-10 lesions, respectively. The deep surgical margin was positive in 15.4%, 4.5%, and 7.7% of the BCC-5, BCC-7, and BCC-10 lesions, respectively. The calculated risk for the positive surgical margin if the BCC-10 lesions were done like the BCC-7 was 15.4%. No recurrence was during follow-up duration. As supported by the findings of the present study, to obtain an adequate hCSM in the high-risk BCC lesions, the iCSM determined according to NCCN recommendations may not be optimal. Nevertheless, after their categorization according to lesion size and disease duration for excision with 5-, 7-, and 10-mm iCSMs, it is possible to obtain a small but important improvement in the outcome of patients.
Ö ÖZ ZE ET T A Am ma aç ç: : Sivas Numune Hastanesi Plastik Cerrahi Polikliniğine baş-boyun bölgesi yerleşimli nonmelanositik cilt kanseri ön tanısıyla konsülte edilen ve eksizyonel biyopsi uygulanan hastalarda yaş, tutulan bölge, lezyon türleri ve kullanılan rekonstrüksiyon tekniklerini belirleyebilmektir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : 1 Ocak 2013-1 Aralık 2014 tarihleri arasında Sivas Numune Hastanesi Plastik Rekonstrüktif ve Estetik Cerrahi Polikliniğine baş-boyun bölgesine yerleşimli nonmelanositik cilt kanseri ön tanısıyla konsülte edilen 163 hastaya yapılan 176 eksizyonel biyopsinin patolojik sonuçları incelenmiştir. B Bu ul lg gu ul la ar r: : Çalış-mamızda incelenen 163 hastanın 80 (%49,07)'ini erkekler, 83 (%50,9)'ünü ise kadınlar oluşturmakta idi. Ortalama yaş 60,4 olarak tespit edildi. Çalışmaya alınan 176 eksizyonel biyopsi sonucunun 105 (%59,6)'ini bazal hücreli karsinom, 14 (%7,9)'ünü skuamöz hücreli karsinom, 5 (%2,8)'ini bazoskuamöz hücreli karsinom, 25 (%14,2)'ini seboreik keratoz, 6 (%3,4)'sını aktinik keratoz, 18 (%10,2)'ini keratoakantom, 1 (%0,56)'ini rüptüre epidermal kist, 1 (%0,56)'ini inflamasyon, 1 (%0,56)'ini granülasyon dokusu oluştur-makta idi. Nonmelanositik cilt kanserinin en sık görülen lokalizasyonu burun idi. S So on nu uç ç: : Çalışmamızda toplam 163 baş-boyun bölgesine lokalize nonmelanositik cilt kanseri ön tanısyla dermatoloji kliniğinden konsülte edilen hastalardan yapılan 176 eksizyonel biyopsi sonucunda 124 (%70,4) adet nonmelanositik cilt kanseri tespit edilirken, 24 (%13,6) adet premalign lezyon saptanmıştır. En sık görülen nonmelanositik cilt kanseri bazal hücreli karsinom olurken, ikinci sıklıkla skuamöz hücreli karsinom görülmüştür. Sonuç olarak, nonmelanositik cilt kanserleri şüphesi olan lezyonlara %70,4 oranında klinik olarak doğru malignite tanısı konulmuştur.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Karsinom, bazal hücre; karsinom, skuamöz hücre; baş ve boyun neoplazileri; patoloji A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : We aimed to determine age, gender, localization area and types of lesions and reconstruction tecniques, suspicion of nonmelanoma skin cancer cases who were consulted from dermatology clinic localizated at head and neck. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Retrospective review of 163 patients undergoing exicion biopsy at the Sivas Numune Hospital Plastic Reconstructive Surgery Clinic for suspicion of nonmelanoma skin cancer localized at head and neck region, between January 2013 and December 2014 was undertaken. 176 excision material of 163 cases were searched. R Re es su ul lt ts s: : In this study 163 patients (80; 49.07% males, 83; 50,9% females) were evaluated. Average of year was 60,4. Of the 175 exision material; 105 (60 %) were basal cell carcinoma, 13 (14.2%) were squamous cell carcinoma, 5 (2.8%) were basosquamous cell carcinoma, 25 (14.2%) were seboreic keratosis, 18 (10.2%) were keratoacanthoma, 6 (3.4%) were actinic keratosis, 1 (0.57%) was ruptured epider...
Objective: The porous polyethylene implant (PPEI) is one of the most commonly used alloplastic materials in cranio-maxillofacial surgery. It is widely preferred because of its biocompatible, durable, flexible and thin nature as well as for its low complication rates. The purpose of the present study was to review the clinical and surgical outcomes of PPEI usage for orbital floor fractures. Methods: The present study included 76 patients who underwent orbital floor fracture reconstruction using PPEI between July 2000 and July 2018. All demographic characteristics of the patients were recorded and the patients were questioned and/or examined whether there was any complaint or complication secondary to the surgery. Results: The mean age of the patients was 35.2 years with a male predominance. The most common causes of injury were in-vehicle traffic accidents, falls, physical assaults and pedestrian accidents, respectively. 73 patients had other concomitant fractures of the facial bones along with the orbital floor fracture. The mean time between the injury and the surgical repair was eight days. Scleral show was observed in two patients (2.6%) due to scar contracture of the subciliary incision whereas one patient had surgical removal of the PPEI. Conclusion: The present study revealed that PPEI is a reliable and flexible material for the reconstruction of orbital floor fractures with a low risk of complications. To prevent or minimize postoperative complications, the orbital septum must be repaired meticulously.
BACKGROUND: Fibronectin (FN) is an indispensable part of the extracellular matrix. During regeneration or wound healing, the plasma form of FN is incorporated into the fibrin clots to form a temporary fibrin-FN matrix, and also locally synthesized cellular FN migrates to the clot to regenerate the injured tissue. We aimed to examine wound tissue FN EIIIB and plasma FN EIIIB expression levels in an experimental wound healing model in rabbits. METHODS:Plasma and tissue EIIIB splice variant expressions were measured serially with RT-qPCR in a cutaneous wound model of rabbits.RESULTS: Tissue FN expression increased as beginning on day 3 and continued to increase on days 6 and 9, reaching maximum expression at day 12 before starting to decrease. On the contrary to the tissue levels, plasma FN levels gradually decreased until day 15 when expression returned to the initial values. CONCLUSION:The findings of the current study support that tissue EIIIB expression level increases during wound healing; and plasma EIIIB expression level decreases minimal changed. This is in contrast to reports where plasma FN provisionally helps ECM formation. Therefore, our data show an essential role of EIIIB at the tissue level in accelerating the wound healing process. The RT-qPCR method in our experimental setup can provide more accurate and precise results compared to the antibody-based methods.
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