Introduction: Aluminum Phosphide "ALP" tablets are frequently used to commit suicide in developing countries and Egypt. Mortality is very high; it can induce oxidative stress and alter antioxidant defense system. Aim of the Work: This study aimed to evaluate malondialdehyde "MDA" and total antioxidant capacity "TAC" as oxidative stress biomarkers in acute ALP poisoning and correlated them with poisoned patients' outcome and mortality. Subjects and Methods: This study was conducted on 120 individuals of both sexes divided into; (Group I) included 60 acute ALP poisoning patients, presented within 6 hours of exposure to Toxicology Unit of Emergency Hospital, Mansoura University and the remaining 60 (Group II) were healthy individuals as control group. Results: Serum level of MDA was significantly increased and TAC was significantly reduced in ALP poisoned group at time of presentation in comparison to control group. On the other hand, levels of MDA and TAC were statistically significant difference between survivors and expired groups. In addition, serum MDA and TAC were found to be sensitive in prediction of ALP mortality. However, MDA level showed maximum specificity as well as more accuracy for prediction of poor outcomes. Conclusions: It can be concluded that, ALP exerts its toxicity through developing disproportionate oxidative stress and compromising antioxidant protective mechanisms. Both MDA and TAC were sensitive in prediction of ALP mortality and serum MDA level could be used as a more sensitive specific predictor biomarker for poor prognosis in acute ALP poisoning.

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This study aims to investigate the oxidative stress role in the pathogenesis of amiodarone-induced pulmonary toxicity and to show whether antioxidants´ coadministration with amiodarone could exert any protective effect. The study was carried out on 36 Sprague-Dawley males, rats were divided into the following six equal groups, drugs were given by gastric tube every day for 7 days as follow; control group: received distilled water, amiodarone (AM) treated group: received amiodarone (100 mg / kg body weight), L-carnitine (LC) treated group: received L-carnitine (100 mg/kg body weight), vitamin C treated group: received vitamin C (1 mg/100 g body weight), amiodarone and L-carnitine treated group: received amiodarone along with LC and amiodarone and vitamin C treated group: Received amiodarone together with vitamin C. The histopathological findings showed that amiodarone disrupted lung architecture and caused inflammatory cells infiltration in addition to extensive fibrosis. Increased level of Malondialdehyde (MDA) and decreased level of catalase (CAT) in lung tissue homogenates were observed in the AM-treated group. Administration of L-carnitine and vitamin C improved the biochemical and histopathological alterations in the lungs induced by amiodarone. Vitamin C was more protective than LC as regard the histopathological changes. Antioxidants administration induced a significant decrease in MDA and an increase in CAT in lung tissue as compared with AM treated group. The oral administration of LC and vitamin C reversed the biochemical and histopathological alterations induced by AM. They may have a protective role in the AM-induced lung toxicity.

Introduction: Preterm birth (PTB) is a worldwide cause of infant mortality and morbidity. Prenatal exposure to endocrine disrupting chemicals (EDCs) especially bisphenol A (BPA) is questioned as a potential risk factor for PTB. Lower gestational vitamin D levels are associated with various maternal and fetal complications. Aim of the Work: This study aimed to evaluate the gestational exposure to BPA and the potential association between urinary BPA and serum vitamin D levels in a sample of Egyptian women having spontaneous PTB. Subjects and Methods: This study was conducted on 106 reproductive aged females divided into Group I with full term delivery (37-42 weeks gestational age) as "control group" and Group II with spontaneous preterm contractions (24 -˂37 weeks gestational age) that ended with preterm delivery as "PTB group". Results: The median level of urinary uncorrected and specific gravity (SG)-corrected BPA was found to be higher in PTB group with high statistically significant difference between both studied groups (P<0.001). Vitamin D deficiency (≤ 20 ng/ml) was detected in 35.8% of PTB cases with a statistically significant difference (P=0.001) among the studied groups. There was statistically significant strong negative correlation (P<0.001) between serum vitamin D and both urinary uncorrected and SGcorrected BPA among the PTB group. Conclusions: high Urinary BPA and low vitamin D levels represent possible predictive environmental risk factors for PTB.

In the morphometry of the patella, there are several naturally occurring variations. Few studies have focused on these anatomical differences among the Egyptian population. The present work aimed to evaluate age and gender variations in different morphometric patellar measurements using magnetic resonance imaging (MRI) in the Egyptian population. Nine patellar parameters were measured on 200 individuals "100 males and 100 females", aged from 20 to 70 years old using knee joint MRI obtained retrospectively from the picture archiving and communication system (PACS) of Radiology Department, Mansoura University. The mean values revealed statistically significant differences across gender for 5 out of 9 patellar measurements and 4 out of 9 across age, denoting sex and age differentiation in patellar morphology among the Egyptian population. Patellar height (PH), width (PW), thickness (PT), lateral facet width (PLFW), and facet thickness (PFT) showed statistically significant sexual dimorphism (p≤ 0.05) in all age groups. On the other hand, patellar angle (PA) showed the highest statistically significant difference (p ≤ 0.001) for age estimation in all age groups. PH, PW, and PLFW showed a statistically significant negative correlation with age. Moreover, patellar measurements showed high accuracy rates for sex determination among the Egyptian population (84.3-93.6%) in different age groups. Morphometric patellar measurements obtained by non-invasive MRI examination were shown to be useful for sex determination and age prediction in the Egyptian population.

Silver nanoparticles, “AgNPs”, represent a prominent nanoproduct, but most of the previous toxicity studies on its genotoxicity are still limited. The current study aimed to assess the genotoxicity of AgNPs on lymphocyte cells using comet assay and to study the recovery probability. It was conducted on 50 adult male albino rats divided into “Control group”, 10 rats were injected intraperitoneal, “IP”, with distilled water for 28 days, and “Test groups”, 40 rats were injected “IP” with 13 ± 3 nm AgNPs for 28 days, subdivided into group I: 10 rats were injected with 2 mg/kg AgNPs, group Ia: 10 rats were injected with 2 mg/kg AgNPs and left for another 4 weeks without scarification, group II: 10 rats were injected with 4 mg/kg AgNPs, and group IIa: 10 rats were injected with 4 mg/kg and left for another 4 weeks without scarification. There was a highly significant decrease in head parameters with an increase in tail parameters in both groups I and II and in group II more than group I. Moreover, there was a highly significant increase in head parameters with a decrease in tail parameters in group Ia compared with the control group and group IIa. Comets were classified according to the tail intensity and according to visual scoring for DNA damage, which revealed different grades of DNA damage with a degree of reversibility after 4 weeks stoppage of exposure. It could be concluded that AgNPs were considered to cause harmful genotoxic effects to the human body in a dose-dependent manner.

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