Malondialdehyde and Total Antioxidant Capacity as Predictors Biomarkers of Mortality in Acute Aluminium Phosphide Poisoning

Abstract

Introduction: Aluminum Phosphide "ALP" tablets are frequently used to commit suicide in developing countries and Egypt. Mortality is very high; it can induce oxidative stress and alter antioxidant defense system. Aim of the Work: This study aimed to evaluate malondialdehyde "MDA" and total antioxidant capacity "TAC" as oxidative stress biomarkers in acute ALP poisoning and correlated them with poisoned patients' outcome and mortality. Subjects and Methods: This study was conducted on 120 individuals of both sexes divided into; (Group I) included 60 acute ALP poisoning patients, presented within 6 hours of exposure to Toxicology Unit of Emergency Hospital, Mansoura University and the remaining 60 (Group II) were healthy individuals as control group. Results: Serum level of MDA was significantly increased and TAC was significantly reduced in ALP poisoned group at time of presentation in comparison to control group. On the other hand, levels of MDA and TAC were statistically significant difference between survivors and expired groups. In addition, serum MDA and TAC were found to be sensitive in prediction of ALP mortality. However, MDA level showed maximum specificity as well as more accuracy for prediction of poor outcomes. Conclusions: It can be concluded that, ALP exerts its toxicity through developing disproportionate oxidative stress and compromising antioxidant protective mechanisms. Both MDA and TAC were sensitive in prediction of ALP mortality and serum MDA level could be used as a more sensitive specific predictor biomarker for poor prognosis in acute ALP poisoning.

Oxidative Stress Parameters, Can They Predict Mortality in Acute Aluminum Phosphide Poisoning?

“…In the present study, there was a relation between MDA and catalase activity and the outcome, as elevated MDA level and declined catalase activity are associated with poor outcome while SOD has no significant relation to the outcome. Another study declared that MDA significantly increases among the non-survivors (13) . The results showed no significant difference in SOD in both survivors and non survivors as well (16) .…”

“…This may be attributed to the low price of AlP and its easy availability without any legal restriction. In addition, young females are more psychologically vulnerable due to social, economic or family troubles (13,14) .…”

Influence of Physical Activity and Cup Orientation on Metal Ion Release and Oxidative Stress in Metal-on-Metal and Ceramic-on-Metal Total Hip Arthroplasty

“…The discrepancies observed between the aforementioned studies could be related to methodological differences in evaluating oxidative stress. We evaluated oxidative stress by measuring MDA and TAC, as these markers are the most frequent indicators of lipid peroxidation and have been used in other studies [59,[63][64][65].…”

Effect of Tramadol on the Development of Chick Embryos

“…To combat ROS and reduce their damage, living organisms have evolved complex antioxidant systems. The TAC of the system is equal to the amount of endogenous antioxidants [65,66].…”