Without controlling outdoor transmission, the goal of elimination of malaria is unlikely to be reached. This is particularly the case in places like Cambodia where people spend considerable amounts of time away from houses at night. Metofluthrin is a synthetic pyrethroid insecticide with a high vapor action at ambient temperatures and has been developed as a long lasting insect repellent device that works without the need to apply heat. Emanators of 10% of metofluthrin were therefore tested in landing collections against potential malaria vectors from three areas of the country (Pailin, Pursat and Koh Kong). One to four emanators were hung on wire 1m off the ground on one or four sides of a square 1.5m from collectors. Collections were also undertaken with Furvela tent-traps.2086 hrs of landing collection were undertaken in Pailin, 528hrs in Veal Veng and 320 in Kroh Salau. Rate ratios were used to determine the significance of the difference between collections. The principal anophelines collected varied between locations. Anopheles minimus s.l. was the most common mosquito in Pailin, An. maculatus s.l in Veal Veng and An. sinensis in Kroh Salau. Among all species collected in Pailin landing rates were reduced by 50% (95% CI 55-44%) when a single emanator was used and by 58% (95% CI 63-52%) when four were used. The effect was greater in An.minimus s.l 51% ( 95% CI 54-47%) and 70% (72%-66%) respectively. A similar result was obtained in Pursat, where 67% (95% CI 66-42%) reductions were observed when four emanators were in use, but no significant reduction was observed in Koh Kong. Although the results show promise it is argued that the product needs further development. IntroductionAn increase in the time to clearance of Plasmodium falciparum infections from three to six days following treatment with artemisinin in Cambodia is a major concern for malaria control worldwide (Dondorp et al., 2011, Smith Gueye et al., 2014 PrePrints (Kheang et al, 2011). Many cases, however, may be acquired when people go to the forest for logging activities or when watching television before they go to bed, times and situations when bednets make little difference. Hence the challenge lies in protecting people at these times and in these places. One way might be to use repellents to prevent mosquitoes biting, and a number of products have been developed with this in mind (Chattopadhyay et al., 2013,Kweka et al., 2012, Revay et al., 2013.The recent development of synthetic pyrethroid insecticides with high vapor action at ambient temperature, has led to the development of devices that work without the need to apply heat (Ogoma et al., 2012, Ujihara et al., 2004 Metofluthrin is a repellent that shows promise as an active ingredient when The formulation previously used was, however, effective for only a few days. A formulation of 5% metofluthrin on a plastic lattice, designed to control evaporation rates, reduced resting mosquito densities inside houses in Indonesia for a month (Kawada et al., 2006). When used in houses in Bagamoyo,...
Without controlling outdoor transmission, the goal of elimination of malaria is unlikely to be reached. This is particularly the case in places like Cambodia where people spend considerable amounts of time away from houses at night. Metofluthrin is a synthetic pyrethroid insecticide with a high vapor action at ambient temperatures and has been developed as a long lasting insect repellent device that works without the need to apply heat. Emanators of 10% of metofluthrin were therefore tested in landing collections against potential malaria vectors from three areas of the country (Pailin, Pursat and Koh Kong). One to four emanators were hung on wire 1m off the ground on one or four sides of a square 1.5m from collectors. Collections were also undertaken with Furvela tent-traps.2086 hrs of landing collection were undertaken in Pailin, 528hrs in Veal Veng and 320 in Kroh Salau. Rate ratios were used to determine the significance of the difference between collections. The principal anophelines collected varied between locations. Anopheles minimus s.l. was the most common mosquito in Pailin, An. maculatus s.l in Veal Veng and An. sinensis in Kroh Salau. Among all species collected in Pailin landing rates were reduced by 50% (95% CI 55-44%) when a single emanator was used and by 58% (95% CI 63-52%) when four were used. The effect was greater in An.minimus s.l 51% ( 95% CI 54-47%) and 70% (72%-66%) respectively. A similar result was obtained in Pursat, where 67% (95% CI 66-42%) reductions were observed when four emanators were in use, but no significant reduction was observed in Koh Kong. Although the results show promise it is argued that the product needs further development.PeerJ reviewing PDF | (v2014:12:3521:0:1:NEW 18 Dec 2014) Reviewing ManuscriptPeerJ PrePrints | http://dx.doi.org/10.7287/peerj.preprints.751v1 | CC-BY 4.0 Open Access | rec PrePrintsWe particularly thank, the ever cheerful, Tep Phalla for his assistance in the field and his exemplary driving. JDC would like to thank Frederic Bourdier and Pen Mony for welcoming JDC into their family and Barney for his company.Without the co-operation and enthusiasm of the collectors in all the study sites the study would not have been possible. Thanks to Olivier Briet of the Swiss Tropical Health Institute, Basle, for reviewing the manuscript and improving the English. We thank Brian Farragher and Holly Prescott of the Liverpool School of Tropical Medicine for providing the analysis of the data used in the supplementary file 1. References
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