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31Organophosphate flame retardants are emerging environmental contaminants, 32 although knowledge of their health risks is limited. Here, thyroid hormone 33 homeostasis and neuronal development was studied in the progeny of adult zebrafish 34 exposed to tris (1, 3-dichloro-2-propyl) phosphate (TDCPP). Adult zebrafish were 35 exposed to TDCPP (0, 4, 20, and 100 µg/L) for 3 months. Increased generation of 36 reactive oxygen species and reduced survival rates was observed in exposed F1 larvae. 37We also observed a significant decrease in plasma thyroxine and amino butyric acid and histamine. Larval locomotion was significantly decreased in 43 exposed fish, but there was no effect on acetylcholinesterase activity. 44Bioconcentration of TDCPP was observed in F0 fish. TDCPP was also detected in F1

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