Bioconcentration, metabolism and neurotoxicity of the organophorous flame retardant 1,3-dichloro 2-propyl phosphate (TDCPP) to zebrafish

In vitro assessment of thyroid hormone receptor activity of four organophosphate esters

“…Moreover, the results of numerous animal experiments have indicated the disruptive effect of OPEs on the thyroid endocrine system. Wang et al (2013Wang et al ( , 2015aWang et al ( , 2015b found that TDCPP changed TH levels and altered the transcription of genes involved in the hypothalamic-pituitary-thyroid (HPT) axis in zebrafish embryos/larvae. Liu et al (2013a) evaluated the effects of TDCPP and TPP on six receptor-associated expression of mRNA in zebrafish embryos/ larvae, and the results showed that TH receptor-centered gene networks were altered by OPEs.…”

“…Toxicology studies have shown that exposure to OPEs has the potential to cause developmental toxicity (McGee et al, 2012), neurotoxicity (Wang et al, 2015a(Wang et al, , 2015b, adverse reproductive (Liu et al, 2013b), disruption to the endocrine system (Liu et al, 2012) and a range of other systemic effects in experimental animal models (Dishaw et al, 2014). However, knowledge of the toxicological mechanisms of OPEs remains limited.…”

Developmental exposure to the organophosphorus flame retardant tris(1,3-dichloro-2-propyl) phosphate: Estrogenic activity, endocrine disruption and reproductive effects on zebrafish

“…Using the same zebrafish as the present study, we have previously shown that long-term exposure to TDCPP can result in neurotoxicity (Wang et al, 2015). Here, we examined the impact of long-term, low dose TDCPP exposure on zebrafish reproduction.…”

Multigenerational effects of tris(1,3-dichloro-2-propyl) phosphate on the free-living ciliate protozoa Tetrahymena thermophila exposed to environmentally relevant concentrations and after subsequent recovery

“…Using the model aquatic organism and ciliated protozoa T. thermophila, it has been found that acute exposure to TDCIPP decreases biomass by reducing number of cells, size of cells and quantity of cilia (Li et al, 2015b). Furthermore, two studies have reported that chronic exposure to relatively small concentrations of TDCIPP resulted in bioconcentration of the chemical, which resulted in adverse effects on reproduction and developmental of F 0 zebrafish (Wang et al, 2015b(Wang et al, , 2015c; TDCIPP was also detected in F 1 eggs following parental exposure, causing developmental neurotoxicity in F 1 larvae of zebrafish (Wang et al, 2015b). Recently, effects of TDCIPP on development have been evaluated in zebrafish and the water flea (Crustacea; Daphnia magna) exposed to environmentally relevant concentrations (Li et al, 2015a;Zhu et al, 2015).…”

“…Published data suggest that exposure to TDCIPP causes various toxicities depending on organisms tested, such as endocrine disruption (Kojima et al, 2013;Liu et al, 2013;Zhang et al, 2014;Wang et al, 2015a), neural toxicity (Dishaw et al, 2011(Dishaw et al, , 2014Ta et al, 2014;Wang et al, 2015bWang et al, , 2015c, hepatoxicology (Crump et al, 2012;Farhat et al, 2013Farhat et al, , 2014aFarhat et al, , 2014bLiu et al, 2016) and developmental and reproductive toxicity (Liu et al, 2012;Liu et al, 2013;McGee et al, 2012;Farhat et al, 2013;Fu et al, 2013;Wang et al, 2015a). For example, acute exposure to TDCIPP affects embryonic development by delaying remethylation of the zygotic genome and embryonic epiboly and results in significantly greater mortality in embryos of zebrafish (McGee et al, 2012;Fu et al, 2013).…”