Developmental exposure to the organophosphorus flame retardant tris(1,3-dichloro-2-propyl) phosphate: Estrogenic activity, endocrine disruption and reproductive effects on zebrafish

Wang, Qiangwei; Lam, James C.W.; Han, Jian; Wang, Xianfeng; Guo, Yongyong; Lam, Paul K.S.; Zhou, Bingsheng

doi:10.1016/j.aquatox.2015.01.014

Cited by 139 publications

(72 citation statements)

References 57 publications

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“…Toxicological data suggest that TDCIPP and TPHP are reproductive toxins [28, 29] and have carcinogenic [30], neurotoxic [31–33] and endocrine-disrupting properties [34–39]. Currently, available data are very limited on human exposure [10, 11, 40–42] and data on potential human health effects are lacking.…”

Section: Introductionmentioning

confidence: 99%

Levels of Urinary Metabolites of Organophosphate Flame Retardants, TDCIPP, and TPHP, in Pregnant Women in Shanghai

Feng

Ouyang

Liu

et al. 2016

Journal of Environmental and Public Health

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Flame retardants are widely used in consumer products to reduce their flammability. Previously used flame retardants have been sequentially banned due to their environmental and human toxicity. Currently, tris(1,3-dichloropropyl) phosphate (TDCIPP) and triphenyl phosphate (TPHP) are among the most commonly used flame retardants. TDCIPP and TPHP are reproductive toxins and have carcinogenic, neurotoxic, and endocrine-disrupting properties. Although high levels of TDCIPP and TPHP have been found in drinking water, seawater, and office air in China, data regarding human exposure are lacking. In this study, we assessed the level of urinary TPHP and TDCIPP metabolites (DPHP and BDCIPP, resp.) in a cohort of pregnant women (N = 23) from Shanghai, China, using liquid chromatography-tandem mass spectrometry. DPHP were detected in 100% urine samples, while only four urine samples had detectable level of BDCIPP in this cohort (17% detected). Geometric means of DPHP and BDCIPP concentrations were 1.1 ng/mL (interquartile range [IQR]: 0.6, 1.5 ng/mL) and 1.2 ng/mL (IQR: 0.6, 2.2 ng/mL), respectively. In this small cohort, urinary DPHP and BDCIPP levels were not significantly correlated with miscarriages, neonatal birthweight, gestational diabetes, or maternal age. These data suggest that exposure to TPHP is widespread, and they demonstrate the feasibility of using urinary biomarkers to measure exposures to modern flame-retardant chemicals.

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Section: Introductionmentioning

confidence: 99%

Levels of Urinary Metabolites of Organophosphate Flame Retardants, TDCIPP, and TPHP, in Pregnant Women in Shanghai

Feng

Ouyang

Liu

et al. 2016

Journal of Environmental and Public Health

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“…Additionally, in this study, it was observed that exposures to EE 2 and Fad interfere with the cell proliferation balance in zebrafish gonad. In general, EE 2 (Luzio et al, 2015b(Luzio et al, , 2016a and other xenoestrogens (Tokumoto et al, 2004(Tokumoto et al, , 2005Wang et al, 2015c) have been pointed to as promoters of zebrafish gonad development, corroborating the slight tendency of JUN to increase in all types of gonads exposed to EE 2 . Since JUN is involved in ovarian differentiation and development, the increase of the relative volumes of this protein in response to EE 2 reinforces the fact that estrogens have a crucial role in female development (Fenske and Segner, 2004;Guiguen et al, 2010;Luzio et al, 2015bLuzio et al, , 2016a.…”

Section: Tablementioning

confidence: 81%

Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17α-ethinylestradiol and fadrozole exposures

et al. 2016

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“…It was shown that TDCPP exposure caused developmental toxicity in zebrafish, including decreasing the hatching and survival rates, body weight and length, and increasing malformation rates. Long‐term exposure disturbed the endocrine, decreased the production of eggs, and further reduced the fecundity of zebrafish (Liu et al , ; Wang et al ; Dishaw et al ; Zhu et al ; Wang et al ). Furthermore, TDCPP exposure reduced chicken embryo mass and growth parameters (Farhat et al ).…”

Section: Discussionmentioning

confidence: 99%

Tris(1,3‐dichloro‐2‐propyl) phosphate disturbs mouse embryonic development by inducing apoptosis and abnormal DNA methylation

Yin

Chen

et al. 2019

Environ and Mol Mutagen

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Tris(1,3‐dichloro‐2‐propyl) phosphate (TDCPP) is a kind of additive flame retardants (FRs) and was found to affect early embryonic development in zebrafish; however, there are few studies to investigate whether TDCPP will disturb the development of early mouse embryos. In our studies, we used mouse embryos as models to study the toxicology of TDCPP on the early embryos. The results showed that TDCPP disturbed the development of early mouse embryos in a dose‐dependent manner. 10 μM TDCPP decreased the blastocyst formation and 100 μM TDCPP was a lethal concentration for the mouse embryos. We proved that TDCPP was detrimental to embryonic development potential by increasing the reactive oxygen species level and inducing early apoptosis. Furthermore, TDCPP changed the DNA methylation patterns of imprinted genes in treated blastocysts. The methylation of H19 and Snrpn promoter regions was increased from 37.67% to 46.00% and 31.56% to 44.38% in treated groups, respectively. In contrast, Peg3 promoter region methylation was declined from 86.55% to 73.27% in treated embryos. Taken together, our results demonstrated that TDCPP could adversely impair the early embryonic development in mouse. Environ. Mol. Mutagen. 2019. © 2019 Wiley Periodicals, Inc.

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Developmental exposure to the organophosphorus flame retardant tris(1,3-dichloro-2-propyl) phosphate: Estrogenic activity, endocrine disruption and reproductive effects on zebrafish

Cited by 139 publications

References 57 publications

Levels of Urinary Metabolites of Organophosphate Flame Retardants, TDCIPP, and TPHP, in Pregnant Women in Shanghai

Levels of Urinary Metabolites of Organophosphate Flame Retardants, TDCIPP, and TPHP, in Pregnant Women in Shanghai

Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17α-ethinylestradiol and fadrozole exposures

Tris(1,3‐dichloro‐2‐propyl) phosphate disturbs mouse embryonic development by inducing apoptosis and abnormal DNA methylation

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