In patients with ADHD/SUDs, combined DRD4 7R and DAT1 10/10 could index MPH reduced DAT occupancy. This might be important for clinical trials, in terms of better understanding individual variability in treatment response.
OBJETIVO: Validar a proposta do desenvolvimento de um ambiente colaborativo virtual para formação de pessoal em medicina nuclear. MATERIAIS E MÉTODOS: No desenvolvimento inicial do ambiente foram levantadas as premissas, restrições e funcionalidades que deveriam ser oferecidas aos profissionais da área. O protótipo foi desenvolvido no ambiente Moodle, incluindo funcionalidades de armazenamento de dados e interação. Um estudo piloto de interação no ambiente foi realizado com uma amostra de profissionais especialistas em medicina nuclear. Análises quantitativas e de conteúdo foram realizadas a partir de um questionário semiestruturado de opinião dos usuários. RESULTADOS: A proposta do ambiente colaborativo foi validada por uma comunidade de profissionais que atuam nesta área e considerada relevante visando a auxiliar na formação de pessoal. Sugestões de melhorias e novas funcionalidades foram indicadas. Observou-se a necessidade de estabelecer um programa de formação dos moderadores no ambiente, visto que são necessárias características de interação distintas do ensino presencial. CONCLUSÃO: O ambiente colaborativo poderá permitir a troca de experiências e a discussão de casos entre profissionais localizados em instituições de diferentes regiões do País, possibilitando uma aproximação e colaboração entre esses profissionais. Assim, o ambiente pode contribuir para formação inicial e continuada de profissionais que atuam em medicina nuclear.
Background The coexistence of amyotrophic lateral sclerosis (ALS) with clinical forms of Parkinson disease (PD), although uncommon, is found to a greater degree than one would expect by chance. The pathological mechanisms of ALS and PD are still not fully understood, and the coexistence of these two diseases suggests that they could share mechanisms in common.
Objective Here we present a sample of patients with clinically definitive or probable ALS who were evaluated with single-photon emission computed tomography SPECT/TRODAT and compared with non-ALS controls.
Methods Patients with clinically definite or probable ALS were assessed with the amyotrophic lateral sclerosis functional rating scale (ALSFRS) to define severity and had their demographic data collected. The TRODAT results of patients with ALS were compared with those of patients with a diagnosis of PD with less than 10 years of duration, and with patients with a diagnosis of others movement disorders not associated with neurodegenerative diseases.
Results A total of 75% of patients with ALS had TRODAT results below the levels considered normal; that was also true for 25% of the patients in the control group without neurodegenerative disease, and for 100% of the patients in the PD group. A statistically significant difference was found between patients with ALS and the control group without neurodegenerative disease in the TRODAT values < 0.05.
Conclusions Our study fits with the neuropathological and functional evidence that demonstrates the existence of nigrostriatal dysfunction in patients with ALS. Further research to better understand the role of these changes in the pathophysiological process of ALS needs to be performed.
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