Our data showed that white matter lesion is more extensive as disease duration increases, especially in mucopolysaccharidosis type II patients. MRI and magnetic resonance spectroscopy findings did not correlate with either enzymatic or glycosaminoglycan levels.

With resting-state functional MRI (rs-fMRI) there are a variety of post-processing methods that can be used to quantify the human brain connectome. However, there is also a choice of which preprocessing steps will be used prior to calculating the functional connectivity of the brain. In this manuscript, we have tested seven different preprocessing schemes and assessed the reliability between and reproducibility within the various strategies by means of graph theoretical measures. Different preprocessing schemes were tested on a publicly available dataset, which includes rs-fMRI data of healthy controls. The brain was parcellated into 190 nodes and four graph theoretical (GT) measures were calculated; global efficiency (GEFF), characteristic path length (CPL), average clustering coefficient (ACC), and average local efficiency (ALE). Our findings indicate that results can significantly differ based on which preprocessing steps are selected. We also found dependence between motion and GT measurements in most preprocessing strategies. We conclude that by using censoring based on outliers within the functional time-series as a processing, results indicate an increase in reliability of GT measurements with a reduction of the dependency of head motion.

O presente estudo objetiva investigar a capacidade de identificação de situações de maus tratos domésticos em escolas e como se dá o encaminhamento deste problema no âmbito escolar. Utilizou-se uma amostra de 90 profissionais da educação, 10 diretores e 80 professores de 10 escolas públicas do Município de São Paulo, que responderam a um questionário previamente elaborado a partir de um estudo piloto com 30 professores. Os resultados indicaram que estes profissionais conseguem identificar várias situações e características de maus tratos domésticos, mas não são capazes de solucionar adequadamente estes casos, pois procuram orientar os pais em vez de encaminhá-los aos serviços de proteção à criança e ao adolescente. Este procedimento pode colocar ainda mais em risco a integridade das vítimas. A temática da violência doméstica é tratada com receio no ambiente escolar e os profissionais da educação ainda se mostram despreparados para abordar esta questão.

The COVID-19 pandemic has forced many people, including those in the fields of science and engineering, to work from home. The new working environment caused by the pandemic is assumed to have a different impact on the amount of work that women and men can do from home.Particularly, if the major burden of child and other types of care is still predominantly on the shoulders of women. As such, a survey was conducted to assess the main issues that biomedical engineers, medical physicists (academics and professionals), and other similar professionals have been facing when working from home during the pandemic. A survey was created and disseminated worldwide. It originated from a committee of International Union for Physical and Engineering Sciences in Medicine (IUPESM; Women in