Aluminum powder was thermally stressed by annealing and quenching, then the powder was non-uniformly dispersed in air and examined for dust combustion behavior as a function of stress-altering conditions. An explosion chamber with a powder injector, spark gap igniter, pressure sensor, spectrometer, and high-speed camera was used for experimentation. Aluminum powder was annealed to 573 K, held for 15 min, and quenched at a rate of 200 K/min (pre-stressed, PS) or 900 K/min (super-quenched, SQ). The untreated (UN), PS, and SQ Al powders were injected into the chamber, and pressure, temperature, and flame spreading behavior were analysed. SQ Al powder exhibited lower pressurization rates than that of PS Al, which was also lower than that of UN Al. Surface modifications to the stress-altered powders may affect their dispersion and suspension in the air environment, which affects flame spreading and pressurization rate. Specifically, annealing powders caused the removal of surface hydration that had two effects: increased the surface energy of the particles (confirmed with density functional theory calculations) and decreased surface roughness (suggested from previous work revealing loss of a nanostructure at the surface with annealing). These two surface modifications may inhibit powder dispersion such that pressurization rate is reduced compared with UN Al powder.
Highly metastatic prostate cancer cells flowing through a microfluidic channel form plasma membrane blebs: they form 27% more than normal cells and have a lower stiffness (about 50%). Hypo-osmotic stress assays (with 50% osmolarity) show 22% more blebbing of highly metastatic than moderately metastatic and 30% more than normal cells. Plasma membrane blebbing is known to provide important metastatic capabilities to cancer cells by aiding cell detachment from the primary tumor site and increasing cell deformability to promote cell migration through the extracellular matrix. Increased blebbing was attributed by others to decreased phosphorylated ezrin, radixin, and moesin (ERM) ( p-ERM) protein expression-p-ERMs bind the plasma membrane to the actin cortex and reduced p-ERM expression can weaken membrane-cortex attachment. Myosin II also influences blebbing as myosin's natural contraction generates tension in the actin cortex. This increases cellular hydrostatic pressure, causes cortex rupture, cytoplasm flow out of the cortex, and hence blebbing. Highly metastatic cells are surprisingly found to express similar ezrin and myosin II levels but higher moesin levels in comparison with lowly metastatic or normal cells-suggesting that their levels, contrary to the literature [G.
This study applies a comprehensive surrogate-based optimization techniques to optimize the performance of polymer electrolyte membrane fuel cells (PEMFCs). Parametric cases considering four variables are defined using latin hypercube sampling. Training and test data are generated using a multidimensional, two-phase PEMFC simulation model. Response surface approximation, radial basis neural network, and kriging surrogates are employed to construct objective functions for the PEMFC performance. There accuracies are tested and compared using root mean square error and adjusted R-square. Surrogates linked with optimization algorithms, i.e., genetic algorithm and particle swarm optimization are used to determine the optimal design points. Comparative study of these surrogates reveals that the kriging model outperforms the other models in terms of prediction capability. Furthermore, the PEMFC model simulations at the optimal design points demonstrate that performance improvements of around 56–69 mV at 2.0 A/cm2 are achieved with the optimal design compared to typical PEMFC design conditions.
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