Purpose: To evaluate the effectiveness of Metronidazole (MTZ) and Chlorhexidine (CHX) gels if used alone or in combination in the treatment of periodontal inflammation Materials and Methods: A Randomized clinical trial, was conducted at the Department of Periodontology, Liaquat University of Medical and Health Sciences, in which patient having moderate to severe periodontitis, assessed by using CPTIN community periodontal index, and bleeding index. Participants were randomly allocated to one of the three groups, Group A -CHX gel Group B – MTZ gel Group C - MTZ gel, and CHX gel both (MTZ –CHX). Furthermore, these indexes were assessed at the 4th, 8th and 12th weeks, and questions were recorded for any adverse effects. Data was analyzed using (SPSS) ANOVA– test used for comparison within groups and finally Repeated measure ANOVA-test was used for intergroup evaluation. Results: A significant improvement in the periodontal status and bleeding index was observed in all treatment groups from the treatment groups when compare baseline scores to all follow-up weeks, mean periodontal status of CHX (baseline:2.7776, 4th week:1.2463, 8th week:2.230, 12th week 0.848) MTZ (baseline: 2.548, 4th week:1.7120, 8th week:1.988, 12th week:1.109) CHX+MTZ (baseline: 2.333, 4th week 1.2432, 8th week 1.482, 12th week:0.524 with p-value 0.0001, However bleeding index showed significant results at the 12th week (CHX:0.825, MTZ:0.125, CHX+MTZ:0.124) with the p-value 0.005 Conclusion: Adjunctive use of topical gels showed significant improvements in clinical and numerical parameters in periodontitis. Keywords: Localized; Metronidazole, Chlorhexidine, Periodontium; inflammation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.