<p><strong>Background: </strong>Literature and other available research states lots of comparison between endoscopic and conventional septoplasty. The study helps conclude the merits and demerits of both techniques and compares the superiority of one method over the other on various aspects from surgeon’s and patient’s point of view. The objective of the study was to compare outcomes of conventional and endoscopic septoplasty.<strong></strong></p><p><strong>Methods: </strong>Study included 48 patients having symptomatic deviated nasal septum willing for surgery randomly divided into two groups of 24 each who underwent endoscopic septoplasty and conventional septoplasty. All the patients selected for study, were assessed for subjective and objective evaluation pre-operatively and post-operatively on 7<sup>th</sup> day, 1 month and 3 months. The study was conducted at Surat Municipal Institute of Medical Education and Research (SMIMER), Surat.</p><p><strong>Results: </strong>There are technical advantages of using endoscope during septoplasty as it is definitely superior from surgeon’s point of view but there is no significant difference in terms of functional outcome, complications and post-operative hospital stay.</p><p><strong>Conclusions: </strong>There are technical advantages of using endoscope being superior in terms of illumination, preciseness and surgery, visualization of deeper parts of nasal cavity and resection of posterior deviation and spur especially in isolated septal spur and in achieving hemostasis. The study helps us conclude that endoscopic septoplasty has merits over conventional septoplasty on various aspects.</p>
<p>Amongst various differential diagnoses possible for intra-oral (palatal) mass, possibility of fibro-lipoma is extremely rare but documented in literature, and hence should be a consideration. Such patient requires thorough evaluation and step-wise approach to treat. This case study documents for a 30-year-old male patient presenting with such mass and chief complaints of post nasal drip, nasal obstruction (right side>left side) and intermittent headache for 3 years. After radiological and endoscopic examination, the mass was surgically removed in toto via dual route (trans-oral and endoscopic). Lipomas are uncommon tumors in the oral cavity, and palate being the rarest amongst them as is our case. It would be strongly advocated to keep lipoma in the differential diagnosis when evaluating a palatal mass. Also, it is worth mentioning and recommending that a careful radiological examination of large lesions arising from the palate is a must before approaching for surgery.</p>
Background: Case study of 30 years male having suspending mass found over upper surface of soft palate hanging in nasopharynx. Methods: After evaluation, patient underwent combined approach (Trans-oral + Endoscopic) excision. Results: Histopathological examination concluded possibility of intra-oral lipoma. Conclusion: Palatal mass (lipoma) requires surgical excision post complete evaluation.
During an earthquake, failure of structure starts at points of weakness. This weakness arises due to discontinuity in mass, stiffness and geometry of structure. The structures having this discontinuity are termed as Irregular structures. Irregular structures contribute a large portion of urban infrastructure. The irregularity in the building structures may be due to irregular distributions in their mass, strength and stiffness along the height of building. Irregularities such as mass, stiffness, plan, and torsion are one of the major reasons of failures of structures during earthquakes. So, the effect of these four irregularities in the seismic performance of structures becomes really important. Height-wise changes in stiffness and mass render the dynamic characteristics of these buildings different from the regular building. When such buildings are constructed in high seismic zones, the analysis and design become more complicated. There are two types of irregularities vertical and plan irregularity as per IS 1893(part 1):2016. The behavior of the multi-storey building of regular and irregular design under earthquake is problematical, and the variations of wind loads are implicit to act consecutively with earthquake loads. In the proposed project, a multi-storey (G + 4) RCC buildings with four irregularities (stiffness, mass, plan, torsion) are studied for earthquake and wind loads using response spectrum method (dynamic analysis) and STADD PRO. These analyses are carried out by considering seismic zone IV, and the behavior assessed by taking the Medium Soil. In this study effects of different irregularities are analysed based on storey displacement, storey drift, and storey shear.
<p class="abstract"><strong>Background:</strong> Tracheostomy is a common surgical procedure used to achieve a secure airway in patients in elective as well as emergency conditions. Our study accounts for our first-hand experience with the procedure in our tertiary multi-speciality hospital.</p><p class="abstract"><strong>Methods:</strong> It is a four year (January 2017 to February 2021) retrospective study in which all the 246 cases of tracheostomies were taken into account which were performed during this study period in the department of otorhinolaryngology (ENT), Surat Municipal Institute of Medical Education and Research (SMIMER), Surat (India). The patients were thoroughly followed up until the final outcome of the tracheostomy was established. </p><p class="abstract"><strong>Results:</strong> A total of 246 tracheostomies were performed, 63.82% of which were in men. The mean patient age was 42 years. The majority (76%) were elective, performed for various indications, while the remaining 24% were emergency tracheostomies. All tracheostomies were performed by otorhinolaryngologists. Complications relating to tracheostomy were documented in 40 patients (16%) intra-operatively and/or post-operatively which included bleeding, surgical emphysema, granulations along the stomal site and rarely shock. The mean time to decannulation was 13.48 days.</p><p class="abstract"><strong>Conclusions:</strong> Our study takes into account and discusses the findings of all the 246 tracheostomies which were performed during the study period of 4 years. Elective cases form the majority although there is a significant case series of emergency tracheostomies performed for a range of pathologies.</p><p class="Default"> </p>
Aims: Healthcare and pharmaceutical research are incessantly reaching to new zeniths which is substantiated by the increasing numbers of diagnostic and therapeutic options available to healthcare professionals for treating patients but a major impediment to this growth has been the evolution of genetic mutation that makes diagnosis and treatment an enigmatic job. Unfortunately, the study of etiology of mutations is still a very neonatal area of research due to the high number of different factors involved in cellular signal trafficking, several metabolic pathways and their simultaneous effects. Owing to these reasons it has been very difficult to select an appropriate treatment modality based on the manifestations of certain common mutations in a pack of symptoms especially in patients who are resistant to treatment. This has led to the development of personalized therapy which can be delineated as acclimatizing of medical treatment based on the characteristics of the individual being treated. This development leans on our understanding of how an individual ingrained molecular and genetic profile makes them prone to certain diseases. To discover a right target for personalized therapies a long screening proses along with In vivo and in vitro analysis are needed. To begin with this review is an attempt to summarize the information available for personalized therapies.
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