Fenofibric acid is an active form of fenofibrate which has an antihyperlipidemic effect. Fenofibric acid belongs to BCS class II, which has low solubility and high permeability. The aim of this study was to form multicomponent crystal of fenofibric acid and saccharin that can increase the solubility and dissolution rate, as well as impact on its effectiveness. The ratio of the mixture of fenofibric acid and saccharin was determined using two phase diagram. Characterizations were carried out by Differential Scanning Calorimetry (DSC), X-Ray Diffraction (XRD), Fourier Transform Infrared (FTIR), and the evaluations carried out are solubility, dissolution rate and antihyperlipidemic effectiveness. Based on the two phase diagram a mixture of fenofibric acid and saccharin produce eutectic point at 1:1 mole ratio. Multicomponent crystal showed a decrease in melting point with DSC analysis, no new crystalline phase was formed in X-ray diffraction analysis and did not show any chemical interactions in FTIR analysis. Multicomponent crystal showed an increase in the solubility and dissolution rate. The results of the effectiveness of antihyperlipidemic showed that multicomponent crystal was more effective than fenofibric acid.
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