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Level IV, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

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Students tend to learn genetics by rote and may not realise the interrelationships in daily life. Because reasoning abilities are necessary to construct relationships between concepts and rote learning impedes the students' sound understanding, it was predicted that having high level of formal reasoning and adopting meaningful learning orientation would improve students' understanding of genetics concepts. To test this hypothesis, relationships among students' understanding of genetics concepts, reasoning ability and learning approaches were investigated. A total of 586 eleventh-grade students participated in the study. Students' reasoning ability and learning orientation were measured using the Test of Logical Thinking and the Learning Approach Questionnaire, respectively. Students' understanding of fundamental genetics concepts was assessed using the Two-tier Genetics Concepts Test. Regression analyses were conducted to examine predictive influence of reasoning ability and learning orientations on students' understanding of genetics concepts. The results revealed that all cognitive variables investigated accounted for a statistically significant portion (27%) of the variance in students' understanding of genetics concepts. Reasoning ability and meaningful learning orientation predicted students' understanding of genetics concepts in a positive direction, rote learning orientation predicted it in a negative direction. Additionally, the results indicated that reasoning ability explained more of the variance in test scores as compared to learning approaches.

Background/aim: Due to nanomaterials' potential benefits for diagnosis and treatment, they are widely used in medical applications and personal care products. Interaction of nanomaterials, which are very small in size, with tissue, cell and microenvironment, can reveal harmful effects that cannot be created with chemically identical and larger counterparts in biological organisms. In this review, a challenge for future medicine, nanotoxicity of nanomaterials is discussed. Materials and methods: A detailed review of related literature was performed and evaluated as per medical applications of nanomaterials their toxicity. Results and conclusion: Most authors state "the only valid technology will be nanotechnology in the next era"; however, there is no consensus on the impact of this technology on humankind, environment and ecological balance. Studies dealing with the toxic effect of nanomaterials on human health have also varied with developing technology. Nanotoxicology studies such as in vivo-like on 3D human organs, cells, advanced genetic studies, and-omic approaches begin to replace conventional methods. Nanotoxicity and adverse effects of nanomaterials in exposed producers, industry workers, and patients make nanomaterials a double-edged sword for future medicine. In order to control and tackle related risks, regulation and legislations should be implemented, and researchers have to conduct joint multidisciplinary studies in various fields of medical sciences, nanotechnology, nanomedicine, and biomedical engineering.

The very rare isolated medial humeral condyle fractures in children and adolescents pose significant problems to orthopedic surgeons such as ulnar nerve injury, trochlear irregularities, fishtail deformity and motion loss. Six adolescent boys with displaced medial humeral condyle fractures with an average age of 14.8 (range 12-17) were included in this study. Patients were followed-up with a mean of 39.8 months (range 21-72). In three patients, there were clinical signs of ulnar nerve dysfunction at initial presentation. Of these, two had only mild hypoesthesia on the ulnar side. The other patient had sensory and motor loss of ulnar nerve at initial presentation complicated by hypothenar atrophy and anhydrosis during follow-up. Complete recovery was seen in this patient only at 2 years. One patient without a neurologic compliant at initial presentation developed mild hypoesthesia on the ulnarly innervated areas postoperatively with complete resolution. Medial skin incision was used for open reduction and internal fixation. No signs of gross morphologic damage were seen on the nerve. The symptoms resolved postoperatively in 3 months time in three of the patients, but in the remaining one, it took 2 years for complete resolution of the symptoms. Also, trochlear irregularity and fishtail deformity were seen on radiographs of two different patients. In all but one patients, motion loss ranging from 10° to 20° was evident on physical examination. The most important finding of this study revealed that transient ulnar nerve dysfunction was seen two-thirds of the patients in this series than any other series reported previously. In three series, only one case of ulnar nerve injury was reported from a total of 19 patients. A possible explanation for such a difference may be the older age in this series.

We report a 16-year-old soccer player with a displaced avulsion fracture of the ischial tuberosity sustained during a soccer match. Open reduction and internal fixation were performed using a longitudinal incision and subgluteal approach. The patient returned to sports 6 months following the operation and returned to his preoperative performance at the 16th month postoperative follow-up. Surgical treatment is often avoided for these types of fractures due to complications associated with the sciatic nerve and exposure difficulty. However, we believe that this incision is a safer alternative to existing methods, providing sufficient exposure and avoiding damage to the neurovascular structures. This article aims to review this alternative incision in the surgical treatment of avulsion fractures of the ischial tuberosity.