Multisystemic inflammatory syndrome (MIS-C) diagnosis remains difficult because the clinical features overlap with Kawasaki disease (KD). The study aims to highlight the clinical and laboratory features and outcomes of patients with MISC whose clinical manifestations overlap with or without KD. This study is a retrospective analysis of a case series designed for patients aged 1 month to 18 years in 28 hospitals between November 1, 2020, and June 9, 2021. Patient demographics, complaints, laboratory results, echocardiographic results, system involvement, and outcomes were recorded. A total of 614 patients were enrolled; the median age was 7.4 years (interquartile range (IQR) 3.9–12 years). A total of 277 (45.1%) patients with MIS-C had manifestations that overlapped with KD, including 92 (33.3%) patients with complete KD and 185 (66.7%) with incomplete KD. Lymphocyte and platelet counts were significantly lower in patients with MISC, overlapped with KD (lymphocyte count 1080 vs. 1280 cells × μL, p = 0.028; platelet count 166 vs. 216 cells × 10 3 /μL, p < 0.001). The median serum procalcitonin levels were statistically higher in patients overlapped with KD (3.18 vs. 1.68 µg/L, p = 0.001). Coronary artery dilatation was statistically significant in patients with overlap with KD (13.4% vs. 6.8%, p = 0.007), while myocarditis was significantly more common in patients without overlap with KD features (2.6% vs 7.4%, p = 0.009). The association between clinical and laboratory findings and overlap with KD was investigated. Age > 12 years reduced the risk of overlap with KD by 66% ( p < 0.001, 95% CI 0.217–0.550), lethargy increased the risk of overlap with KD by 2.6-fold ( p = 0.011, 95% CI 1.244–5.439), and each unit more albumin (g/dl) reduced the risk of overlap with KD by 60% ( p < 0.001, 95% CI 0.298–0.559). Conclusion : Almost half of the patients with MISC had clinical features that overlapped with KD; in particular, incomplete KD was present. The median age was lower in patients with KD-like features. Lymphocyte and platelet counts were lower, and ferritin and procalcitonin levels were significantly higher in patients with overlap with KD. What is Known: • In some cases of MIS-C, the clinical symptoms overlap with Kawasaki disease. • Compared to Kawasaki disease, lymphopenia was an independent predictor of MIS-C. What is New: • Half of the patients had clinical features that overlapped with Kawasaki disease. • In patients whose clinical features overlapped with KD, procalcitonin levels were almost 15 times higher than normal. • Lethargy increased the risk of overlap with KD by 2.6-fold in MIS-C pa...
Araştırmalar / Researches ÖZET:Alt solunum yolu enfeksiyonu olan çocuk hastalarda viral etkenlerin immunofluoresan ve immunokromatografik yöntemler ile araştırılması Results: In 122 (46.9%) of samples the virus was identified. RSV was the most common etiologic viral agent in LRTI by a rate of 35.3% followed by influenza A virus 4.2%, influenza B virus 1.9%. Conclusion:In pediatric population, rapid diagnosis of LRTIs will help us to protect children and to choose appropriate treatment, avoidance of unnecessary antibiotic use and prevention of nosocomial infections caused by these agents.
INTRODUCTION: Ventriculo-peritoneal shunt infection is the most important complication of shunt applications. In pediatric age, shunt infections are associated with shunt dysfunction, requirement for shunt revision, neurodevelopmental delay, prolonged hospital stay, and high treatment costs. In this study, we aimed to evaluate the characteristics of shunt infections of our patients and to compare the differences between early and late infections, infections caused by staphylococci and other strains and infection that did and did not recur. METHODS: In this retrospective study, shunt infections treated in the Pediatric Infection Clinic of Hamidiye Etfal Training and Research Hospital between July 2008 and July 2011 were evaluated. RESULTS: Forty-seven shunt infections in 42 patients were evaluated. Congenital anomalies were the most common etiology of hydrocephalus and fever was the most common symptom of the patients. Higher rates of early shunt infections, shunt infections in early childhood and infections caused by staphylococci species were observed. Patients with infections caused by staphylococci species received shorter duration of antibiotherapy (p=0.024). Infections that recurred in the six months of follow-up had higher rates of positive blood cultures (p=0.022). There was no statistically significant difference between early and late-term shunt infections. DISCUSSION AND CONCLUSION: Shunt infections were evaluated in different aspects in our study. Direct colonization of the shunt catheter still seems to be most important cause for the shunt infections because early infections and infections caused by skin flora were more common in our patient group.
Acute osteoarthritis is a serious, hematogenously spread pyogenic infection of bone and joint which is rarely encountered in newborn period and often develops secondary to invasive procedures. As in many diseases seen in neonatal period, its diagnosis may be difficult and delayed because of nonspecific signs and symptoms. Poor prognosis is related to permanent sequelae in cases with delayed diagnosis and treatment. In this case report, 15 days old newborn with acute osteoarthritis on shoulder is presented with clinical, laboratory and radiologic features of the disease along with current diagnostic and therapeutic approaches. Soft tissue edema and movement restriction detected in neonatal period should be evaluated for osteoarthritis and treated quickly and effectively especially in patients with history of hospitalization. The main goal should be minimizing the possibility of sequelae with early surgical drainage and proper antibiotherapy against infectious agent with a multidisciplinary approach. The Journal of Pediatric Research 2014;1(2):95-8 Key Words: Newborn, osteoarthritis ÖZET Akut osteoartrit, kemik ve eklemin yenidoğan döneminde nadir görülen hematojen yayılımlı ciddi piyojenik enfeksiyonudur ve sıklıkla invazif girişimlere sekonder gelişmektedir. Yenidoğan döneminde bir çok hastalıkta olduğu gibi semptom ve bulguların nonspesifik olmasından dolayı tanısı zordur ve genellikle gecikir. Tanı ve tedavisi geciken vakalarda kalıcı sakatlıklara sebep olabilme potansiyeli olduğundan dolayı prognozu kötüdür. Bu olgu sunumunda omuz bölgesinde akut osteoartrit saptanan 15 günlük yenidoğan bebekte; hastalığın yenidoğan dönemindeki klinik, laboratuvar ve radyolojik özellikleri, güncel tanı ve tedavi yaklaşımları eşliğinde sunulmuştur. Yenidoğan döneminde yumuşak dokuda saptanan ödem ve hareket kısıtlılığı, özellikle hastanede yatış anamnezi veren olgularda osteoartrit açısından ele alınarak değerlendirilmeli, hızlı ve etkin bir şekilde tedavi edilmelidir. Erken cerrahi drenaj ve etkene yönelik uygun antibiyoterapi ile sekel olasılığını minimale indirmeye çalışmak temel hedef olmalıdır. Bu hedefi gerçekleştirirken klinik yaklaşımın multidisipliner olması gereklidir.
Anafilaksi ve Anafilaksideki Gelişmeler
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.