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Selenium and Mercury are two chemical elements studied in several fields of knowledge due to their chemical properties and interactions. The aim of this study was to analyze the evolution of research activity from 1700 to 2017 on the global trend of these elements, we carried out a bibliometric analysis using the Scopus database. For each keyword accessed (“selenium”, “selenide”, “selenite”, “selenate”, “organoselenium”, “mercury”, “inorganic mercury”, “mercury vapor” and “methylmercury”), we analyzed the publication output, and the top 5 geographic distribution of publications and contributing authors, as well as the top 5 Scopus subject categories where the documents are indexed. The results demonstrated an increase in the number of publication over time for all the keywords. Research about Selenium and its inorganic and organic chemical forms, and Mercury and its inorganic and organic chemical forms were described in approximately 117,000 and 164,000 documents, respectively. United States was the country with the highest number of published documents in all the keywords analyzed. Chemistry, Medicine and Environmental Science were the subject categories with the highest number of documents. Researchers from the United States, China, Japan, Slovenia, and Brazil were in the ranking of the most productive authors. To our knowledge, this is the first bibliometric study on Selenium and Mercury and can be useful to identify potential research groups for scientific collaborations.

Opioid drugs have analgesic properties used to treat chronic and post-surgical pain due to descending pain modulation. The use of opioids is often associated with adverse effects or clinical issues. This study aimed to evaluate the toxicity of opioids by exposing the neuroblastoma cell line (SH-SY5Y) to 0, 1, 10, and 100 µM oxycodone and naloxone for 24 h. Analyses were carried out to evaluate cell cytotoxicity, identification of cell death, DNA damage, superoxide dismutase (SOD), glutathione S-transferase (GST), and acetylcholinesterase (AChE) activities, in addition to molecular docking. Oxycodone and naloxone exposure did not alter the SH-SY5Y cell viability. The exposure to 100 µM oxycodone and naloxone significantly increased the cells’ DNA damage score compared to the control group. Naloxone exposure significantly inhibited AChE, GST, and SOD activities, while oxycodone did not alter these enzymes’ activities. Molecular docking showed that naloxone and oxycodone interact with different amino acids in the studied enzymes, which may explain the differences in enzymatic inhibition. Naloxone altered the antioxidant defenses of SH-SY5Y cells, which may have caused DNA damage 24 h after the exposure. On the other hand, more studies are necessary to explain how oxycodone causes DNA damage.

O escopo do presente estudo é identificar as articulações realizadas no campo da socioeducação para a efetivação da educação escolar, especialmente, no que se refere ao tipo de modalidade de ensino adotada pelas instituições que executam as medidas socioeducativas. As discussões aqui propostas são geradas a partir da busca do entendimento de três fios articuladores: a Educação de Jovens e Adultos (EJA), a socioeducação e a interseção entre estes dois. Para tanto, abordaremos a educação na socioeducação, a escolarização dos adolescentes privados de liberdade ao nível de Brasil e, principalmente, em nível estadual, com enfoque no Amazonas, e a escolha da EJA nesses contextos. Ademais, ao longo da discussão observaremos a incompatibilidade entre as idades de atendimento no sistema socioeducativo e na EJA e, ainda, a inexistência de critérios de avaliação no processo de seleção de profissionais, que levem em consideração o perfil, a formação e qualificação específicos para atuarem diante das particularidades desse público e do espaço em questão. Afinal, a educação sistemática e assistemática, formal ou não formal, se constitui como fator preponderante no processo de socioeducação.Palavras-chave: Sistema socioeducativo; Educação escolar; Educação de Jovens e Adultos (EJA).Youth and Adult Education for adolescents in conflict with the law: school education in socioeducationABSTRACTThe scope of this study is to identify the articulations made in the field of socioeducation for the implementation of school education, especially regarding the type of education modality adopted by the institutions that carry out the socioeducational measures. The discussions proposed here are generated from the search for the understanding of three connecting threads: Youth and Adult Education (YAE), socioeducation, and the intersection between these two. To do so, we will address education in socioeducation, the schooling of adolescents deprived of their freedom in Brazil, and especially in the state of Amazonas, and the choice of Youth and Adult Education (EJA) in these contexts. Moreover, throughout the discussion, we will observe the incompatibility between the ages of attendance in the socioeducational system and in the EJA, also, the inexistence of evaluation criteria in the process of selection of professionals, that take into consideration the profile, the specific training and qualification to act before the particularities of this public, and of the space in question. After all, systematic and non-systematic education, formal or non-formal, constitutes a preponderant factor in the process of socio-education.Keywords: Socio-Educational system; School education; Youth and Adult Education (YAE).Educación de Jóvenes y Adultos para adolescentes en conflicto con la ley: la educación escolar en la socioeducaciónRESUMENEl objetivo de este estudio es identificar las articulaciones realizadas en el ámbito de la socioeducación para la eficacia de la educación escolar, especialmente en lo que respecta al tipo de modalidad educativa adoptada por las instituciones que llevan a cabo las medidas socioeducativas. Las discusiones aquí propuestas se generan a partir de la búsqueda de la comprensión de tres hilos conductores: la Educación de Jóvenes y Adultos (EPJA), la socioeducación y la intersección entre ambas. Para ello, se abordará la educación en la socioeducación, la escolarización de los adolescentes privados de libertad en Brasil, y especialmente a nivel estatal con un enfoque en Amazonas, y la elección de la EJA) en estos contextos. Además, a lo largo de la discusión, observaremos la incompatibilidad entre las edades de atención en el sistema socioeducativo y en la EJA y también la ausencia de criterios de evaluación en el proceso de selección de profesionales, que tengan en cuenta el perfil, la formación específica y la cualificación para actuar ante las particularidades de este público, y el espacio en cuestión. Al fin y al cabo, la educación sistemática y no sistemática, formal o no formal, se constituye como un factor preponderante en el proceso de socioeducación.  Palabras clave: Sistema socioeducativo; Educación escolar. Educación de Jóvenes y Adultos (EPJA).