Conventional methods to engineer electroconductive hydrogels (ECHs) through the incorporation of conductive nanomaterials and polymers exhibit major technical limitations. These are mainly associated with the cytotoxicity, as well as poor solubility, processability, and biodegradability of their components. Here, we describe the engineering of a new class of ECHs through the functionalization of non-conductive polymers with a conductive choline-based bio-ionic liquid (Bio-IL). Bio-IL conjugated hydrogels exhibited a wide range of highly tunable physical properties, remarkable in vitro and in vivo biocompatibility, and high electrical conductivity without the need for additional conductive components. The engineered hydrogels could support the growth and function of primary cardiomyocytes in both two dimentinal (2D) and three dimensional (3D) cultures in vitro. Furthermore, they were shown to be efficiently biodegraded and possess low immunogenicity when implanted subcutaneously in rats. Taken together, our results suggest that Bio-IL conjugated hydrogels could be implemented and readily tailored to different biomedical and tissue engineering applications.

Inquérito domiciliar transversal que objetivou mensurar a qualidade de vida de idosos rurais com osteoporose e verificar seus fatores associados. Utilizaram-se os instrumentos: estruturados World Health Organization Quality of Life-Bref (WHOQOL-BREF) e Health Organization Quality of Life Assessment for Older Adults (WHOQOL-OLD). Procedeu-se análise descritiva, teste t-Student, Mann Whitney e regressão linear múltipla (p <0,05). Predominou o perfil: sexo feminino, 60|- 70 anos, casada, 4 |- 8 anos de estudo, renda de 1 salário mínimo, aposentados por idade, dona de casa, regular satisfação das necessidades, casa própria quitada e que moravam com o cônjuge. Os menores escores associaram-se ao maior número de morbidades, à ausência de escolaridade e à menor idade. Evidencia-se a necessidade de ações de acompanhamento e monitoramento das condições de saúde desta população, visando minimizar o impacto na qualidade de vida.

Este trabalho objetiva apresentar possibilidades da Ginástica Para Todos (GPT) nas ações do PIBID Interdisciplinar Ler e Ser da UFVJM, projeto aprovado pela Capes e iniciado em 2014, no sentido de contribuir para a formação de leitores de literatura por prazer na Educação Básica. Para tanto, realizamos uma revisão bibliográfica atrelada à proposta do projeto, partindo do pressuposto que a formação do leitor literário é compromisso de todas as áreas. Dessa forma, as licenciaturas em Pedagogia, Letras Português/Espanhol, Letras Português/Inglês e Educação Física da UFVJM iniciam um trabalho interdisciplinar, por meio das ações do PIBID Ler e Ser, visando integrar literatura e corpo por meio da GPT. Apresentamos, ao longo deste texto, conceitos teóricos relacionados aos estudos literários, à GPT e suas articulações, bem como algumas propostas de ação deste PIBID: estímulo aos graduandos e professores da educação básica para participação em grupos de estudos; discussão da importância da utilização do maior número de modalidades de expressão corporal nas propostas de incentivo à leitura; estímulo dos envolvidos para a composição de produções artísticas que dialoguem com as obras ou textos literários lidos, dentre outras. As considerações são ainda iniciais, mas possibilitadoras de ousadas ações e resultados, tanto teóricos como práticos.

Aims and objectives To investigate the association between potentially inappropriate medication use and frailty phenotype among community‐dwelling older adults and to identify factors associated with the use of these drugs according to frailty condition. Background There is insufficient evidence about the association between inappropriate medication use and the condition of frailty, particularly among community‐dwelling older adults. Therefore, data obtained from population surveys should be made available in order to support the development of clinical guidelines about the prevention of frailty. Design This was a cross‐sectional study conducted according to the STROBE Checklist. Methods This population‐based study was conducted on 1,607 older adults. Potentially inappropriate medication use was assessed according to Beers criteria and frailty syndrome was determined according to the phenotype proposed by Fried and colleagues. Data were analysed statistically using multinomial or binary logistic regression models. Results About 13.6% of the subjects were frail, and 36.8% used at least one inappropriate medication. The adjusted model indicated that, the more potentially inappropriate medication use, the higher the prevalence of frailty, prefrailty and the walking slowness component. Female gender, one or more years of schooling, five or more reported morbidities, and instrumental dependence regarding daily life activities were factors associated with potentially inappropriate medication use in the nonfrail group. Conclusion Inappropriate medication use was prevalent among community‐living older adults, and its presence was associated with the occurrence of frailty. Relevance to clinical practice Primary care nurses are the professionals with the greatest contact with the older adults in the community. Thus, the results support the inclusion of the assessment of potentially inappropriate medication use in the routine of nursing consultation. In case of a positive screening, the older person should be referred to geriatric evaluation in order to optimise drug treatment for the prevention of frailty.

to describe the socioeconomic characteristics of the elderly according to cognitive status, and, to associate the cognitive decline with functional disability and depression indicative among the elderly. Methods: this is a quantitative, retrospective and observational study with 92 elderly. The used instruments were: Mini Examination of Mental State; Katz Index; Lawton and Brody Scale and Abbreviated Geriatric Depression Scale. Statistical analysis and chi-square test (p<0.05) were used. Results: elderly with a cognitive decline for females were predominant, 80 years and older, widowed and living with children, with one to three years of study, individual income up to a minimum wage. The proportion of elderly with a dependent cognitive decline in basic activities of daily living (p=0.043) and instrumental activities of daily living (p=0.008) was higher than independent. There were no significant differences in the depression indicative (p=0.437). Conclusion: the proportion of dependent elderly was higher in those with cognitive decline.

Previous studies have shown that males who have AIDS are more frequently affected by infectious diseases than females. The esophagus is the organ in the digestive tube that is more commonly affected by opportunistic infections during the syndrome. The aim of this study was to assess the influence of AIDS and of gender on local immunity of the esophageal epithelium. Fragments of the esophagus from 29 autopsied women and 37 autopsied men were collected at a university hospital from 1980 to 2009 and were divided in groups with and without AIDS. The IgA-, IgG-, and IgM-positive cells and Langerhans cells (LCs) were immunostained, respectively, with anti-IgA, anti-IgG, anti-IgM, and anti-S100. The software Image J was used to measure the esophageal epithelium and to count the epithelium cellular layers. Patients with AIDS, apart from gender, showed an increase in IgA-, IgG-, and IgM-positive cells and a reduction of Langerhans cells, in thickness and in number of cellular layers in the esophageal epithelium. However, among individuals with AIDS, men presented lower secretory expression of IgA-, IgG-, and IgM-positive cells than women and more intense reduction of LCs. Women have naturally presented better local esophageal immunity than men. Although AIDS possibly causes immunological and morphological alterations in the esophageal epithelium in both genders, women have better esophageal immunity, which may explain a greater frequency of hospital admissions due to infection of men with AIDS when compared with women.

Objetivos:verificar a prevalência de violência em idosos nos últimos 12 meses; descrever as características sociodemográficas e econômicas dos idosos segundo o tipo de violência sofrida; verificar os fatores associados à violência e identificar os clusters de violência contra idosos no município de Uberaba, Minas Gerais.Métodos:Trata-se de um  estudo transversal e quantitativo realizado com 581 idosos da comunidade de Uberaba, Minas Gerais.Procederam-se as análises estatísticas:descritiva e regressão logística múltipla (p≤0,05). Resultados:A violência física e/ou psicológica e a psicológica obtiveram maiores percentuais entre aqueles com 1├5 anos de estudo e que residiam com filhos. A menor idade associou-se à violência física e/ou psicológica. Os maiores aglomerados foram na região sudeste do município. Conclusão: Os idosos mais novos sofrem mais episódios de violência física e/ou psicológica, assim como aqueles com menor escolaridade, que residem com os filhos e na região sudeste do município.

Objectives: To describe the sociodemographic, clinical and pharmacotherapy characteristics of elderly persons with metabolic syndrome and to identify factors associated with drug interactions among these individuals. Method: A quantitative, analytical and transversal study was carried out among 263 elderly people with metabolic syndrome in the urban area of Uberaba, Minas Gerais, Brazil. Possible drug interactions were identified and classified according to the Micromedex® DrugReax System. The chi-squared test and the multiple logistic regression model were used for analysis ( p<0.05). Results: The majority of the individuals were female (70.7%); aged 60 to 74 years (72.3%); lived with a spouse/ partner (63.9%); had some schooling (74.1%); an individual monthly income of ≤ one minimum wage (77.1%); lived with others (88.2%); had five or more morbidities (89.7%) and exhibited polypharmacy (73.0%); used potentially inappropriate medications (54.4%) and had possible drug interactions (75.3%). Associated with the possible presence of drug interactions were: age range ( p=0.005), polypharmacy ( p<0.001) and use of potentially inappropriate medications ( p=0.006). Conclusion: Possible drug interactions were associated with increased age, polypharmacy and the use of potentially inappropriate medications. This study contributes to knowledge of these possible interactions among elderly people with metabolic syndrome, and as such can be considered an important tool for planning actions to ensure the safety of these individuals who, due to the complexity of their treatment, use multiple medications.