Introduction: Diabetes mellitus (DM) is characterized by hyperglycemia accompanied with the biochemical alterations in carbohydrate, protein and lipid metabolism. Diabetics have been shown to be in procoagulant state due to abnormalities in several plasma proteins in blood coagulation.Measurement of prothrombin time (PT), activated partial thromboplastin time (APTT), bleeding time and clotting factor concentration are usually done in patients with a suspected abnormal coagulation. The present study was planned to assess and compare the coagulation tests in patients with T2DM and healthy individuals.
Material and methods:In this prospective case control study 50 diabetic patients and 50 healthy non-diabetic individuals were were subjected to Prothrombin time(PT), Activated partial thromboplastin time(APTT) and D-Dimer assay patients in the department
Results:A stastically significant increase in Mean Prothrombin time (PT) levels of 17.48 in cases vs 14.52 in controls with a P value was 0.012. The Mean aPTT levels in cases was 48.12 and in controls was 30.56 with a P value was 0.001. However, in case of Mean D-Dimer levels, there was no significant difference between cases and controls with a P value of 1.000.
Conclusion:The present study observed a significant association between Type 2 Diabetes mellitus and coagulation parameters. Increased plasma levels of PT and APTT were observed which are consistent with abnormal coagulation mechanisms and may be interpreted as a tendency for bleeding and cardiovascular disorders. It would also be helpful to incorporate coagulation screening as a routine investigations for the better management of diabetic patients.
The present study is an attempt to ascertain the determinants of profitability of automobile industry in India by taking a sample of all the automobile firms covering various segments of automobile industry in India viz. commercial vehicles, three wheelers, two wheelers, and passenger vehicles which are listed on Bombay Stock Exchange (BSE), for a period of eleven years from 2003-04 to 2013-14. In order to achieve the objectives of the study, firm-specific factors viz. financial leverage, size of firm, tangibility of assets, growth of firm, liquidity, inventory turnover ratio, debt equity ratio, debtors turnover ratio, total assets turnover ratio, average payment period, and cash liquidity of firm are regressed against return on assets ratio. Firstly correlation analysis and multiple regression analysis are applied to identify the factors affecting profitability of sample firms. Further, to find out the prominent factors that account for the variation in profitability of sample firms, step-wise regression analysis has been carried out. It was found that profitability of automobile industry in India is significantly influenced by the liquidity position of firm, growth of firm, inventory turnover ratio, debt equity ratio, and average payment period.
Acute chest syndrome (ACS) in sickle cell disease is caused by thromboemboli in the pulmonary vasculature. The diagnostic criteria include the presence of pulmonary infiltrate(s) on chest x-ray. This case report suggests that a V/Q scan may play a diagnostic role in sickle cell patients with symptoms of ACS and a negative chest x-ray. Am.
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