Phosphorylation has long been recognized as the key mediator of protein signaling. New modes of signaling regulation are emerging with the development of specific chemical probes and application of high-throughput mass spectrometry technologies. Using biotintagged chemical probes for protein oxidation, mass spectrometry and functional assays, our group has recently reported isoform-specific oxidation of Akt2 in response to PDGF signaling. The studies included here investigate the functional consequence of oxidation on Akt2-mediated cell migration and cell cycle. Akt2-KO MEFs transduced with WT and Cys124Ser Akt2 were used as the model system for these studies. The implications of these findings on disease pathology are discussed.
We present the first ever neighbourhood-scale portrait of caste-based residential segregation in Indian cities. Residential segregation studies in Indian cities have relied on ward-level data. We demonstrate in this paper that wards cannot approximate an urban neighborhood, and that they are heterogeneous. For a typical ward, the neighbourhood-ward dissimilarity index is greater than the wardcity dissimilarity index. Using 2011 enumeration block (EB) level census data for five major cities in India -Bengaluru, Chennai, Delhi, Kolkata, and Mumbai -we show how patterns of caste-based urban residential segregation operate in contemporary India. We also present the first visual snapshot of castebased residential segregation in an Indian city using georeferenced EB level data for Bengaluru. Besides implications for policy, our analysis also points to the need for publicly available, geospatially-linked neighborhood-scale census data that includes data on economic class for a spatial understanding of economic and social stratification within Indian cities.
We present the first ever neighbourhood-scale portrait of caste-based residential segregation in Indian cities. Residential segregation studies in Indian cities have relied on ward-level data. We demonstrate in this paper that wards cannot approximate an urban neighborhood, and that they are heterogeneous. For a typical ward, the neighbourhood-ward dissimilarity index is greater than the ward-city dissimilarity index. Using 2011 enumeration block (EB) level census data for five major cities in India – Bengaluru, Chennai, Delhi, Kolkata, and Mumbai – we show how patterns of caste-based urban residential segregation operate in contemporary India. We also present the first visual snapshot of caste-based residential segregation in an Indian city using georeferenced EB level data for Bengaluru. Besides implications for policy, our analysis also points to the need for publicly available, geospatially-linked neighborhood-scale census data that includes data on economic class for a spatial understanding of economic and social stratification within Indian cities. En
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