The interception of carbolithiation-derived tertiary benzylic α-lithio piperidines with carbon electrophiles, under HMPA-mediated conditions, has led to the diastereoselective synthesis of vicinally functionalized piperidines bearing α-amino quaternary stereocenters.
Diastereoselective Synthesis of ,,'-Trisubstituted Pyrrolidines and Piperidines by Directed Sequential Lithiation/Alkylation. -(BENG*, T. K.; FOX, N.; Tetrahedron Lett. 56 (2015) 1, 119-122, http://dx.
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