Lupus pernio (LP) is a chronic non-life threatining type of cutaneous sarcoidosis that can be related to chronic fibrotic sarcoidosis, hyperglobulinemia and hypercalcemia. The aim of this case report is to evaluate the clinical and demographic features of cutaneous sarcoidosis mainly presenting with a rare manifestation of LP. In this paper we report a case of systemic sarcoidosis presenting with LP and a review of the available literature. LP is a rare presentation with infiltrated erythematoviolaceous plaques affecting the nose. We address the main management approach, and possible association with an underlying systemic sarcoidosis. LP is a rare but chronic manifestation of systemic sarcoidosis that needs to be treated in order to prevent cosmetic defects and psychological effects. It is important to recognize such a condition early in order to avoid a delay in treatment and worsening of the condition, both physically and psychologically. Further research regarding the diagnostic approach and management is required to understand this condition thoroughly.
PurposeThe aim of this study was to evaluate the progression of a case of a patient with epidermolysis bullosa (EB) since early age who survived to adulthood, presenting with recurrent skin blisters and disfiguring scars and disabling musculoskeletal deformities.BackgroundEB is a rare group of inherited diseases that affect the skin fragility causing it to blister in response to even minor trauma. Established novel treatments are limited in the literature due to its rarity, and more research is needed to set a global management approach. Clinical manifestations range widely from localized to generalized blistering.MethodsA rare case of EB surviving to adulthood despite the complications, which has been evaluated, treated during a relapse, and followed up.ConclusionThe described case is of considerable clinical interest due to its rarity and severity. Optimal management requires a multidisciplinary approach and revolves around the protection of the skin against slightest injury, use of careful wound care dressings, aggressive nutritional support, and early medical or surgical interventions if needed to manage any complications. Prognosis varies considerably depending on each case.
Introduction and aim. Currently, the study of the pathogenesis of rosacea is very important on disorders of microcirculation. Due to the feature of the structure of the eyelid skin microcirculation disorders learning in this area seems an urgent task. The aim of the study was to study the microcirculation of the face skin and eyelid skin in patients with rosacea by laser Doppler flowmetry (LDF) before and after treatment with tacrolimus ointment 0.1 % and 15 % azelaic acid gel, Blefarogel 2 and Blefaroloson. Mathereals and methods. The study involved 70 patients with different clinical forms of rosacea. Patients surveyed microcirculation in the skin of the face and eyelid skin by laser Doppler flowmetry. Patients were divided into 2 groups: who applied 0.1 % tacrolimus ointment on the skin of the face and eyelids and who applied 15 % azelaic acid gel on the face skin, Blefarogel 2 and Blefaroloson on the eyelid skin. A month study was conducted again to measure the effectiveness of the therapy. Results and discussion. Patients with rosacea marked increase in IM (index of microcirculation) in the face skin and the affected eyelid skin. The study of amplitude-frequency spectrum of LDF-grams of the face skin revealed stagnation in the arterial and in the affected eyelids skin - in the venous link microvasculature. In both groups of patients background therapy showed a significant improvement of microcirculation parameters. Conclusions. Laser Doppler flowmetry is an effective method for the investigation of violations of the microcirculation in the skin and the affected eyelid skin in rosacea, as well as to evaluate the effectiveness of therapy in these patients.
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