A study of the microcirculation of the skin and eyelids in patients with rosacea by laser doppler flowmetry

Abstract

Introduction and aim. Currently, the study of the pathogenesis of rosacea is very important on disorders of microcirculation. Due to the feature of the structure of the eyelid skin microcirculation disorders learning in this area seems an urgent task. The aim of the study was to study the microcirculation of the face skin and eyelid skin in patients with rosacea by laser Doppler flowmetry (LDF) before and after treatment with tacrolimus ointment 0.1 % and 15 % azelaic acid gel, Blefarogel 2 and Blefaroloson. Mathereals and methods. The study involved 70 patients with different clinical forms of rosacea. Patients surveyed microcirculation in the skin of the face and eyelid skin by laser Doppler flowmetry. Patients were divided into 2 groups: who applied 0.1 % tacrolimus ointment on the skin of the face and eyelids and who applied 15 % azelaic acid gel on the face skin, Blefarogel 2 and Blefaroloson on the eyelid skin. A month study was conducted again to measure the effectiveness of the therapy. Results and discussion. Patients with rosacea marked increase in IM (index of microcirculation) in the face skin and the affected eyelid skin. The study of amplitude-frequency spectrum of LDF-grams of the face skin revealed stagnation in the arterial and in the affected eyelids skin - in the venous link microvasculature. In both groups of patients background therapy showed a significant improvement of microcirculation parameters. Conclusions. Laser Doppler flowmetry is an effective method for the investigation of violations of the microcirculation in the skin and the affected eyelid skin in rosacea, as well as to evaluate the effectiveness of therapy in these patients.