Head and neck cancer can have a devastating impact on speech and swallowing function. In particular, a tumor in the tongue can reduce the ability to produce articulatory gestures typical for English plosives. Previous case studies suggest that the lower lip can compensate for tongue tip gestures in speech after tongue reconstruction. The goal of this study is to establish typical lower lip movement patterns for alveolar and velar plosives for English speakers towards identifying compensatory lip movements in cancer speakers. Ten participants were recruited with no reported hearing or speech problems. A list of 40 minimal pairs beginning with the target plosives were created and embedded in carrier sentences. The participants read sentences in random order with and without babble noise in a standing posture. Lip motion was captured using a custom app on an iPhone 11 capturing the perioral surface area with the TrueDepth infrared camera. Preliminary results suggest that this app-based approach to lip tracking is a viable tool to capture typical lip movement patterns, ultimately enabling clinical research in more accessible settings. Mixed-effects linear regression analyses of the lip kinematics will be discussed.
Objectives
To determine if relationships exist between maternal concentrations of hepcidin and serum ferritin (SF) throughout pregnancy and infant SF concentrations at 3 months of age.
Methods
Pregnant women from Edmonton and Calgary, Alberta, Canada were recruited into the Alberta Pregnancy Outcomes and Nutrition (APrON) cohort study from 2009–2012. Blood samples were collected from 358 women at each trimester of pregnancy and their infants at 3 months of age. Maternal hepcidin concentrations were assessed using enzyme linked immunosorbent assays. Maternal and infant SF concentrations were measured by chemiluminescent microparticle immunoassays. General linear models and multiple regression models, adjusting for maternal age, ethnicity, pre-pregnancy body-mass-index, and inflammation via direct acyclic graphs, were performed by SAS−9.4.
Results
In the maternal cohort, 63.4% had suboptimal iron stores (SF < 15 ng/mL) during late gestation. Infant SF concentrations were ordered into quartiles arranged by maternal SF and hepcidin concentrations (Q1 being the highest). During the second trimester, women with hepcidin concentrations in Q3 (4.8–9.9 ng/mL) had infants with significantly higher concentrations of SF at 3 months [β = 39.6 ng/mL (11.6,67.6); p = 0.013], compared to those in Q1, Q2, and Q4. Infant SF concentrations were significantly higher when second trimester maternal SF concentrations were in Q2 (31.5–46.5 ng/mL) [β = 33.1 ng/mL (5.6,60.5); p = 0.018] and Q3 (18.0–31.4 ng/mL) [β = 30.8 ng/mL (3.5,58.2); p = 0.027] compared to Q1 and Q4. There were no relationships between maternal SF and hepcidin concentrations during the first or third trimesters and infant SF concentrations. A positive relationship was found between maternal hepcidin and SF concentrations during mid-gestation (P < 0.0001), which may partly explain why higher infant SF concentrations were similarly associated with moderate maternal concentrations of both iron biomarkers.
Conclusions
Second trimester maternal concentrations of SF (18.0–46.5 ng/mL) and hepcidin (4.8–9.9 ng/mL) were associated with higher SF concentrations in 3-month-old infants. Future studies are needed to explore the complex relationships between maternal iron status and infant iron status during the first year of life.
Funding Sources
APrON study by Alberta Innovates, CIHR; J. Evanchuk by CIHR, WCHRI.
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