No abstract

Oxytocin (OT) subserves various physiological, behavioral, and cognitive processes. This paired with the ability to administer OT with minimal and inconsistent side effects has spurred research to explore its therapeutic potential. Findings from single-dose studies indicate that OT administration may be beneficial, at least under certain circumstances. The state of the field, however, is less clear regarding effects from chronic OT administration, which more closely resembles long-term treatment. To address this gap, this review synthesizes existing findings on the use of chronic OT administration in animal and human work. In addition to detailing the effects of chronic OT administration across different functional domains, this review highlights factors that have contributed to mixed findings. Based on this review, a basic framework of interrelated regulatory functions sensitive to chronic OT administration is offered. The paper also identifies future research directions across different contexts, populations, and outcomes, specifically calling for more systematic and standardized research on chronic OT administration in humans to supplement and expand what is currently known from preclinical work.

Age-related differences in cognition and socioemotional functions, and in associated brain regions, may reduce sensitivity to cues of untrustworthiness, with effects on trust-related decision making and trusting behavior. This study examined age-group differences in brain activity and behavior during a trust game. In this game, participants received "breach-of-trust" feedback after half of the trials. The feedback indicated that only 50% of the monetary investment into their fellow players had resulted in returns. The study also explored the effects of intranasal oxytocin on trust-related decisions in aging, based on suggestions of a modulatory role of oxytocin in response to negative social stimuli and perceptions of trust. Forty-seven younger and 46 older participants selfadministered intranasal oxytocin or placebo, in a randomized, double-blind, between-subjects procedure, before they engaged in the trust game while undergoing functional magnetic resonance imaging (fMRI). Younger participants invested less into their game partners after breach-of-trust feedback, while older participants showed no significant difference in their investment after breach-of-trust feedback. Oxytocin did not modulate the behavioral effects. However, after breachof-trust feedback, older participants in the oxytocin group showed less activity in the left superior temporal gyrus. In contrast, older participants in the placebo group showed more activity in left superior temporal gyrus after breach of trust. The findings may reflect reduced responsiveness to cues of untrustworthiness in older adults. Furthermore, the modulatory effect of oxytocin on left superior temporal gyrus activity among older adults supports the neuropeptide's age-differential role in neural processes in aging, including in the context of trust-related decision making.

The degree to which people take advice, and the factors that influence advice-taking, are of broad interest to laypersons, professionals, and policy-makers. This meta-analysis on 346 effect sizes from 129 independent datasets (N = 17, 296) assessed the weight of advice in the judge-advisor system paradigm, as well as the influence of sample and task characteristics. Information about the advisor(s) that is suggestive of advice quality was the only unique predictor of the overall pooled weight of advice. Individuals adjusted estimates by 32%, 37%, and 48% in response to advisors described in ways that suggest low, neutral, or high quality advice, respectively. This indicates that the benefits of compromise and averaging may be lost if accurate advice is perceived to be low quality, or too much weight is given to inaccurate advice that is perceived to be high quality. When examining the three levels of perceived quality separately, advice-taking was greater for subjective and uncertain estimates, relative to objective estimates, when information about the advisor was neutral in terms of advice quality. Sample characteristics had no effect on advice-taking, thus providing no evidence that age, gender, or individualism influence the weight of advice. The findings contribute to current theoretical debates and provide direction for future research.